CHRONIC TOXICITY STUDIES OF CHLOROPROPANOL

1-氯-2-丙醇被用作生产该化合物的化学中间体 环氧丙烷，以及作为生产环氧丙烷 聚氨酯聚合物和环氧丙烷。人类是有潜力的 暴露在这种化学物质中，而且没有足够的啮齿动物毒性 以及致癌性研究。 本合同的目的是研究1-1的长期影响- F344/N大鼠和B6C3F1小鼠体内的氯-2-丙醇。化学物质会 在饮用水中给大鼠和小鼠灌胃2年。在… 研究的结论，组织和器官将被检查 与治疗相关的非肿瘤性或肿瘤性病变。 这些研究的结果将增加我们的理解和知识 接触1-氯-2-丙醇的任何潜在不良影响。

1-Chloro-2-propanol is used as a chemical intermediate for the manufacture of propylene oxide, and as a starting material for the production of polyurethane polymers and propylyene oxide. There is potential for human exposure to this chemical, and there have been no adequate rodent toxicity and carcinogenicity studies. The objective of this contract is to study the long the effects of 1- chloro-2-propanol in the F344/N rat and B6C3F1 mouse. The chemical will be administered to rats and mice in the drinking water for 2 years. At the conclusion of the study, tissues and organs will be examined for treatment-related non-neoplastic or neoplastic lesions. The results of these studies will add to our understanding and knowledge of any potential adverse effects from exposure to 1-chloro-2-propanol.