SUBCHRONIC DOSED WATER STUDIES OF URETHANE

聚氨酯的亚慢性定量水研究

• 批准号: 3638701
• 负责人: ANDREW BRAUN
• 金额: $ 91.81万
• 依托单位: TSI MASON LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-29 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3638701
• 关键词: adduct; alcoholic beverage consumption; alcoholic beverages; chemical carcinogenesis; drug administration routes; drug adverse effect; food additives; laboratory mouse; laboratory rat; polyurethanes; toxicant interaction

Urethane was nominated for study because of widespread exposure of the general population to urethane from alcoholic beverages and a lack of adequate toxicity and carcinogenicity data on the dose-response effects. The objective of this contract is to characterize the toxicity of urethane in Fischer 344 rats and B6C3F1 mice and to examine the effect of ethanol on the toxicity of urethane. Animals will be dosed with urethane, urethand and ethanol, or ethanol in the drinking water for 13-weeks. At the conclusion of the dosing period general toxicity and target organ toxicity will be evaluated.

聚氨酯被提名为研究对象，因为它广泛暴露于