STUDIES OF 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE

下列慢性毒性/致癌性和 1，2-二氢-2，2，4-二氢-2，2，4-的引发/促进研究 三甲基喹啉(TMQ)是要进行的。 1.对F344大鼠和B6C3F1小鼠进行了104周的皮肤涂抹研究 包括3个剂量水平和对照组，包括动物组 每周收到5到3份申请。完全组织病理学 要进行评估。 2.使用雄性F344大鼠进行了为期26周的启动/促进研究 选择进行一项为期72周的研究。这项为期26周的研究涉及 7个治疗组分别测定其数量和大小 GGT病灶。组织病理学仅限于肝脏。可选的 为期72周的研究涉及7个临时牺牲的治疗组 在26周和52周。小组将接受为期72周的治疗或将 接受长达52周的治疗，撤销治疗，动物 坚持到研究结束(72周)。所有组都将拥有 进行有限的组织病理学和GGT评估。 3.对雌性Sencar小鼠进行为期52周的启动/促进研究。一个 初步剂量发现研究将进行21天。这个 这项为期52周的研究涉及13个治疗组，使用3个剂量水平的 TMQ。组织病理学仅限于皮肤和肝脏。

The following chronic toxicity/carcinogenicity and initiation/promotion studies of 1,2-Dihydro-2,2,4- trimethylquinoline(TMQ) are to be conducted. 1. A 104-week skin paint study in F344 rats and B6C3F1 mice which involves 3 dose levels plus controls, including groups of animals receiving 5 or 3 applications/week. Complete histopathologic evaluation is to be done. 2. A 26-week initiation/promotion study using male F344 rats with the option to conduct a 72-week study. The 26-week study involves 7 treatment groups with a determination of the number and size of GGT foci. Histopathology is limited to the liver. The optional 72-week study involves 7 treatment groups with interim sacrifices at 26 and 52 weeks. Groups will be treated for 72 weeks or will be treated for up to 52 weeks, treatment withdrawn and the animals held until the end of the study (72 weeks). All groups will have limited histopathologic and GGT evaluations performed. 3. A 52-week initiation/promotion study in female Sencar mice. A preliminary dose finding study is to be conducted for 21 days. The 52-week study involves 13 treatment groups using 3 dose levels of TMQ. Histopathology is limited to the skin and liver.