Control of allergic lung inflammation

控制过敏性肺部炎症

• 批准号: nhmrc : 1012524
• 负责人: Prof Barbara Fazekas De St Groth
• 金额: $ 31.74万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-allergic-lung-inflammation/109670
• 关键词: Control; allergic; lung; inflammation

Australia has one of the highest asthma rates in the world. In this project we will study how natural regulatory T cells suppress asthma in a mouse model. We will determine where and when interactions between regulatory T cells and allergic T cells occur, and define the mechanisms used by regulatory cells to mediate their suppressive effects. Our findings will aid in understanding why asthma develops and how it may be controlled by the immune system itself.

澳大利亚是世界上哮喘发病率最高的国家之一。在这个项目中，我们将研究自然调节性T细胞如何在小鼠模型中抑制哮喘。我们将确定调节性T细胞和过敏性T细胞之间的相互作用发生在何时何地，并确定调节性T细胞介导其抑制作用的机制。我们的研究结果将有助于理解为什么哮喘会发展以及它如何被免疫系统本身控制。