Dendritic cell-mediated induction of T cell tolerance

树突状细胞介导的 T 细胞耐受诱导

• 批准号: nhmrc : 1051854
• 负责人: Prof Barbara Fazekas De St Groth
• 金额: $ 43.66万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dendritic-cell-mediated-cell-tolerance/112241
• 关键词: Dendritic; cell; mediated; induction; tolerance

Australia has some of the highest rates of immune-mediated diseases in the world. These diseases include autoimmune, allergic and inflammatory conditions. We will use a mouse model to study how dendritic cells can prevent the onset of these conditions by inactivating the immune cells that cause them. Our findings will aid in understanding why these diseases develop and how they may be prevented and treated.

澳大利亚是世界上免疫介导疾病发病率最高的国家之一。这些疾病包括自身免疫性疾病、过敏性疾病和炎症性疾病。我们将使用小鼠模型来研究树突状细胞如何通过灭活引起这些疾病的免疫细胞来预防这些疾病的发生。我们的研究结果将有助于理解这些疾病的发展原因以及如何预防和治疗。