Autoimmunity in double transgenic models of self tolerance

自我耐受双转基因模型中的自身免疫

• 批准号: nhmrc : 115052
• 负责人: Prof Barbara Fazekas De St Groth
• 金额: $ 10.51万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/autoimmunity-double-transgenic-self-tolerance/94399
• 关键词: Autoimmunity; double; transgenic; models; self

The immune system protects the body against infection by means of a population of circulating white blood cells called lymphocytes. Each lymphocyte has on its surface its own particular receptor which recognises only one out of the universe of possible substances. Receptors are generated in a semi-random way, using a combination of elements encoded by the genes, and it is possible to generate receptors that react with the body itself, rather than with invading organisms. If the cells bearing these self-reactive receptors become activated, an autoimmune disease ensues. We are using animal models to study how the body deals with self-reactive cells. We will attempt to activate these cells and thus cause autoimmune disease. The experimental manoeuvres that successfully cause autoimmunity in normal animals will provide clues as to the processes that can cause autoimmune disease.

免疫系统通过一群被称为淋巴细胞的循环白细胞来保护身体免受感染。每个淋巴细胞表面都有自己独特的受体，这种受体只能识别一种可能的物质。受体以一种半随机的方式产生，使用基因编码的元素组合，并且有可能产生与身体本身反应的受体，而不是与入侵的生物体反应。如果携带这些自我反应受体的细胞被激活，就会引发自身免疫性疾病。我们正在使用动物模型来研究身体如何处理自我反应细胞。我们将尝试激活这些细胞从而引起自身免疫性疾病。在正常动物中成功引起自身免疫的实验操作将为引起自身免疫疾病的过程提供线索。