Control of combined simian-human immunodeficiency virus infection utilising NK cells mediating antigen-specific antibody dependent cellular cytotoxicity - a novel vaccine modality

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Recently, progress was made in developing a vaccine against HIV. Our laboratory was selected to join a global collaboration trying to elucidate the key to this success. Attention has focused on non-neutralizing antibodies and our laboratory has developed a unique expertise in detecting such immune responses. This research will define, purify and manufacture these antibodies and test their ability to prevent HIV in animals with the ultimate aim of producing a vaccine for human use.