Control of combined simian-human immunodeficiency virus infection utilising NK cells mediating antigen-specific antibody dependent cellular cytotoxicity - a novel vaccine modality

利用 NK 细胞介导抗原特异性抗体依赖性细胞毒性来控制猿猴-人类免疫缺陷病毒联合感染 - 一种新型疫苗方式

• 批准号: nhmrc : 1034770
• 负责人: Dr Ivan Stratov
• 金额: $ 28.84万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-combined-simian-vaccine-modality/110934
• 关键词: Control; combined; simian; human; immunodeficiency

Recently, progress was made in developing a vaccine against HIV. Our laboratory was selected to join a global collaboration trying to elucidate the key to this success. Attention has focused on non-neutralizing antibodies and our laboratory has developed a unique expertise in detecting such immune responses. This research will define, purify and manufacture these antibodies and test their ability to prevent HIV in animals with the ultimate aim of producing a vaccine for human use.

最近，在研制艾滋病毒疫苗方面取得了进展。我们的实验室被选中加入一项全球合作，试图阐明这一成功的关键。人们的注意力集中在非中和抗体上，我们的实验室在检测这种免疫反应方面具有独特的专业知识。这项研究将定义，纯化和制造这些抗体，并测试它们在动物中预防艾滋病毒的能力，最终目的是生产供人类使用的疫苗。