AGING CELL AND TISSUES

本节目将继续对北极星生物的几个方面进行研究 老化的细胞和组织。生物化学和生物分子的某些方面 正在审查与年龄有关的进程，包括：a) 维生素K依赖的蛋白质羧化与骨的合成 蛋白质、骨钙素；b)骨钙素及其与骨钙素的关系 骨质疏松症和其他骨骼疾病中的脂溶维生素；c) 多胺依赖赖氨酰残基的氨丁化和羟化以及 18000道尔顿亚硫氨酸蛋白的合成 细胞增殖能力的测量；d)脂蛋白代谢和 衰老过程和编码的基因的持续特征 某些载脂蛋白；e)某些重要试剂的设计和使用 它们是基于有机硼中发现的特殊化学特征和 芳香族四元化合物，并使用荧光和硼核磁共振技术。

This program continues investigations on several aspects of the biology of aging cells and tissues. Certain aspects of biochemical and biomolecular processes which are age-dependent are being examined and include: a) vitamin K-dependent protein carboxylation and the synthesis of the bone protein, osteocalcin; b) osteocalcin and its relationships to the lipid-soluble vitamins in osteoporosis and other bone disorders; c) polyamine-dependent lysyl residue aminobutylation and hydroxylation and the synthesis of an 18,000 dalton hypusine-containing protein, which is a measure of cell proliferative capacity; d) lipoprotein metabolism and the aging process and the continued characterization of genes which code for certain apolipoproteins; e) the design and use of certain vital reagents which are based on special chemical features found in organoboron and aromatic quaterary compounds and use fluorescence and boron-NMR techniques.