STEM CELL AGE & XRAY CHEMOTHERAPY & LEUKEMOGENESIS

本研究的主要目的是探讨如何 细胞-细胞信号传导控制细胞事件如分化， 生长和形态发生。 本研究的具体目标是（1） 从遗传学上鉴定信号通路的分子组分， 指定果蝇眼睛中的细胞命运，（2）克隆基因 编码这些组分以用于进一步的功能和结构 分析，（3）生物化学表征每个因素的作用， 信号传导的过程。 使用超级计算机 资源将是获得访问现有的数据库， 和蛋白质序列信息，并利用现有的程序， 以便分析我们研究中产生的序列。 获得这些方案对本研究的目标很重要。 所要求的服务单位数目反映了日常工作的需要， 每天或每周使用。 我请求超级计算机 资源，因为它包含最新和最完整的 我需要访问的数据库 我的本地计算环境 包括Macintosh IIci、Classic II和以太网端口。 由于我是 位于匹兹堡大学， 生物科学，我可以进入大学的VAX。

The primary goals of this research focus on the question of how cell-cell signaling controls cellular events such as differentation, growth, and morphogenesis. Specific goals of this research are to (1) genetically identify molecular components of a signaling pathway that specifies cell fate in the Drosophila eye, (2) clone the genes encoding these components for further functional and structural analysis, (3) biochemically characterize the role of each factor in the process of signal transduction. The use of supercomputer resources will be to gain access to current databases that contain DNA and protein sequence information, and to utilize existing programs in order to analyze sequences that will be generated from our research. Access to these programs is important for the goals of this research. The number of service units requested reflects the need for routine use on a daily or weekly basis. I am requesting supercomputer resources because it contains the most up to d ate and complete databases that I need to access. My local computing environment includes a Macintosh IIci, Classic II, and ethernet port. Since I am located at the University of Pittsburgh at the Department of Biological Sciences, I have access to the University VAX.