STEM CELL AGE & XRAY CHEMOTHERAPY & LEUKEMOGENESIS

这项研究的主要目标集中在如何 细胞-细胞信号控制细胞事件，如分化， 生长和形态发生。本研究的具体目标是(1) 从基因上鉴定信号通路的分子成分 指定果蝇眼睛中的细胞命运，(2)克隆基因 对这些组件进行编码，以获得进一步的功能和结构 分析，(3)生化表征每个因素在 信号转导过程。超级计算机的使用 资源将用于访问当前包含DNA的数据库 和蛋白质序列信息，并利用现有的程序在 以分析我们的研究将产生的序列。 获得这些项目对于本研究的目标非常重要。 所要求的服务单位数反映了例行程序的需要 每日或每周使用。我在请求超级计算机 资源，因为它包含最新和最完整的 我需要访问的数据库。我的本地计算环境 包括Macintosh IIci、Classic II和以太网端口。既然我是 位于匹兹堡大学的 生物科学，我可以访问大学的VAX。

The primary goals of this research focus on the question of how cell-cell signaling controls cellular events such as differentation, growth, and morphogenesis. Specific goals of this research are to (1) genetically identify molecular components of a signaling pathway that specifies cell fate in the Drosophila eye, (2) clone the genes encoding these components for further functional and structural analysis, (3) biochemically characterize the role of each factor in the process of signal transduction. The use of supercomputer resources will be to gain access to current databases that contain DNA and protein sequence information, and to utilize existing programs in order to analyze sequences that will be generated from our research. Access to these programs is important for the goals of this research. The number of service units requested reflects the need for routine use on a daily or weekly basis. I am requesting supercomputer resources because it contains the most up to d ate and complete databases that I need to access. My local computing environment includes a Macintosh IIci, Classic II, and ethernet port. Since I am located at the University of Pittsburgh at the Department of Biological Sciences, I have access to the University VAX.