CANCER RISK IN WOMEN WITH AUGMENTATION MAMMOPLASTY

接受隆胸手术的女性患癌症的风险

• 批准号: 3701668
• 负责人: THEODORE COLTON
• 金额: $ 45.75万
• 依托单位: ABT ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1996-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3701668
• 关键词: abstracting; biomaterial compatibility; biomaterial evaluation; breast surgery; cancer risk; data collection; female; human subject; implant; interview; longitudinal human study; medical records; plastic surgery; polyurethanes; postoperative complications; questionnaires

A retrospective cohort study of approximately 12,000 women with cosmetic augmentation mammoplasty is planned. The women will be assembled from a number of different plastic surgery practices in geographically dispersed areas. Attempts will be made to achieve an average of 10 years of follow-up and to have a sufficient number of women with different types of implants, particularly the polyurethane foam coated types. Medical records will be abstracted for information on patients characteristics and details regarding the types of implants received. The women will be traced to the present time through various mechanisms, and will then be sent a questionnaire to obtain information on subsequent adverse outcomes and risk factors for selected conditions. To determine whether these women experience unusual risks of cancer, comparisons will be made with available cancer incidence statistics. In addition, an internal comparison group of approximately 4,000 patients undergoing other types of plastic surgery will be assembled, traced and questioned in a manner similar to the implant patients. This comparison group will enable evaluation of whether characteristics related to the seeking of plastic surgery have an impact on subsequent disease risk. This internal comparison group will also serve as a base for developing incidence rates of diseases for which population statistics are not available, e.g., the immune conditions that have been linked anecdotally to breast implants.

大约12,000名具有化妆品女性的回顾性队列研究 计划进行增强乳腺成形术。 妇女将从 地理分散的不同整形手术实践的数量 区域。 将尝试平均达到10年 后续行动并拥有足够数量的具有不同类型的女性 植入物，尤其是聚氨酯泡沫涂层类型。 医疗的 记录将被摘要以获取有关患者特征的信息 以及有关收到的植入物类型的详细信息。 女人会 通过各种机制可追溯到当前时间，然后将是 发送问卷调查以获取有关后续不良结果的信息 和选定条件的风险因素。 确定这些是否 妇女会遇到异常的癌症风险，将进行比较 可用的癌症发病率统计。 另外，内部 比较组约4,000例接受其他类型的患者 整形手术将以某种方式组装，追踪和质疑 类似于植入患者。 这个比较组将启用 评估与寻求塑料有关的特征是否 手术对随后的疾病风险有影响。 这个内部 比较组还将作为发展发病率的基础 人口统计数据的疾病，例如 与乳房植入物相关的免疫条件。