Antimicrobial catheters with cell and tissue compatibility

具有细胞和组织相容性的抗菌导管

• 批准号: 9256017
• 负责人: Kennard M Brunson
• 金额: --
• 依托单位: POLYMER EXPLORATION GROUP, LLC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2016-12-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9256017
• 关键词: Adhesions; Adsorption; Agar; Aliquot; Animal Model; Antibiotics; Award; Bacteria; Biocompatible Materials; Candida albicans; Catheters; Cells; Centers for Disease Control and Prevention (U.S.); Characteristics; Charge; Chemicals; Chemistry; Colony-forming units; Coupled; Disabled Persons; Dyes; Economics; Effectiveness; Elderly; Engineering; Enterobacter; Enterococcus; Environment; Equilibrium; Escherichia coli; Evaluation; Exposure to; Goals; Healthcare; Heavy Metals; Histocompatibility; Human; Immersion Investigative Technique; Immunology; In Vitro; Incidence; Infection; Klebsiella pneumonia bacterium; Laboratories; Lead; Left; Length; Measures; Mechanics; Medical Care Costs; Methods; Microbiology; Modeling; Modification; Monitor; Nitrogen; Oryctolagus cuniculus; Patient-Focused Outcomes; Phase; Polymers; Preparation; Process; Pseudomonas aeruginosa; Research; Resistance; Running; ST14 gene; Silicones; Silver; Small Business Innovation Research Grant; Stroke; Surface; Suspension substance; Suspensions; Technology; Testing; Time; United States National Institutes of Health; Urine; Validation; Woman; Work; abstracting; antimicrobial; antimicrobial drug; bacterial resistance; base; biomaterial compatibility; catheter associated UTI; density; design; flasks; improved; in vivo; innovation; killings; medical complication; medical schools; novel strategies; pathogen; patient safety; professor; zeta potential

Polymer Exploration Group LLC PA-14-071 Abstract Project Title: Antimicrobial catheters with cell and tissue compatibility Abstract Catheter associated urinary tract infections (CAUTIs) are often encountered with subsequent antibiotic administration contributing to buildup of bacterial resistance. Leaving behind customary methods including release of silver and antimicrobials, PEG LLC is developing a new approach to produce catheters that kill bacteria but are compatible with human cells. The promise of this new overcoat method is not based on any single characteristic but on an unprecedented combination of features. These include an “intelligent choice” for economical chemistry and processing. Proposed Phase II research is based on a promising paradigm- breaking approach coupled with in vitro and in vivo evaluations designed to assess feasibility and FDA requirements. A strong interdisciplinary team is dedicated to “bottoms up” biomaterials engineering that fills a strong need in the face of “top down” requirements to achieve such unprecedented capabilities economically. Indeed, PEG-LLC research promises to have a major impact not only on improving patient outcomes but in providing an economic benefit in reducing the rapidly rising cost of medical care. Key Words: catheters; overcoat; cell compatibility; antimicrobial;

聚合物勘探集团有限公司PA-14-071摘要