RESOURCE SUPPORT--CHEM/ECONOMIC/BIOL INFORMATION NEEDS

该项目提供了一种机制， 环境和职业癌症领域，包括四个 任务 任务I用于支持NCI癌症病因学部门的 化学品甄选工作组努力甄选和提名 化学品的致癌性生物测定的国家毒理学计划。 癌症病因学部门，NCI，已经并将继续， 候选化学品提名的主要来源。 在任务一下， 进行类别研究（按用途或结构类别分列的化学品）。 从 此类课堂研究和其他来源（IARC专著，特别提名， 体外研究等）选择化学品， 准备好系统地评价和选择候选人， 化学品选择工作组。 本项目任务二支持 国际癌症研究机构的信息需求 （IARC）提供资料，以供列入《 IARC关于人类致癌风险评价的专著。 一个 平均每年在里昂举行三次IARC工作组会议， 法国，通常需要一名承包商代表参加 这些会议。 任务三涉及维护和更新国家癌症研究所的 化学致癌研究信息系统（CCRIS）。 CCRIS是一个 经过科学评估和充分参考的数据库， 致癌性、促肿瘤性、共致癌性、致突变性和， 最近的肿瘤抑制剂测试结果 未来的扩展 数据库设想增加一个流行病学文件。 此文件 不是为了独立，而是作为一个交叉链接， CCRIS中不同文件之间的特定化合物。应包括的数据 由承建商与顾问公司共同评估， 根据NCI提供的既定标准。 CCRIS是常驻机构， 在国家医学图书馆的TOXNET系统中可以搜索到。 下 任务四，编写了特别研究报告，如《物种对物种》， 有机饮用水致癌物代谢的比较与调查 污染物、化学致癌物抑制剂等。 到 确保高质量的任何国家的最先进的报告，根据这一点编写的 任务，这些报告已由内部顾问审查， 在联邦政府之外 这些报告的编写将取决于 关于资金的可用性。 同样在该任务下，生物测定报告 正在编写和更新《简要手册》。 这本手册现在 包含300多个NCI/NTP致癌生物测定技术的摘要 报道

This project provides a mechanism for the development of information in the areas of environmental and occupational cancer and consists of four tasks. Task I is used to support NCI's Division of Cancer Etiology's Chemical Selection Working Group in its effort to select and nominate chemicals to the National Toxicology Program for carcinogenicity bioassay. The Division of Cancer Etiology, NCI, has been, and will continue to be, the primary source for nomination of candidate chemicals. Under Task I, class studies (chemicals by use or structural class) are conducted. From such class studies and other sources (IARC monographs, ad hoc nominations, in vitro studies, etc.) chemicals are selected and summary sheets are prepared to permit systematic evaluation and selection of candidates by the Chemical Selection Working Group. Task II of this project supports the information needs of the International Agency for Research on Cancer (IARC) by providing information for inclusion in Sections 1 and 2 of the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. An average of three IARC working group meetings are held each year in Lyon, France, and a contractor representative is usually required to attend these meetings. Task III deals with the maintenance and updating of NCI's Chemical Carcinogenesis Research Information System (CCRIS). CCRIS is a scientifically evaluated and fully referenced data base containing carcinogenicity, tumor promotion, co-carcinogenicity, mutagenicity and, more recently, tumor inhibitor test results. Future expansion of this data base envisions the addition of an epidemiology file. This file is not intended to stand by itself but rather serve as a cross-linkage on specific compounds between the various files in CCRIS. Data to be included in CCRIS are evaluated by contractor, in consort with consultants, according to established criteria provided by NCI. CCRIS is resident and searchable in the National Library of Medicine's TOXNET system. Under Task IV, special studies have been prepared such as Speciesto-Species Comparison of Carcinogen Metabolism, Survey of Organic Drinking Water Contaminants, Inhibitors of Chemical Carcinogens, amongst others. To assure high quality of any state-of-the-art reports prepared under this task, such reports have been reviewed by consultants from within and outside the Federal government. Preparation of such reports will depend on availability of funding. Also under this task, the Bioassay Report Summary Handbook are being compiled and updated. This handbook now contains summaries of over 300 NCI/NTP Carcinogenesis Bioassay Technical Reports.