RESOURCE SUPPORT--CHEM/ECONOMIC/BIOL INFORMATION NEEDS

资源支持--化学/经济/生物信息需求

• 批准号: 3626293
• 负责人: ABRAHAM MITTELMAN
• 金额: $ 3.9万
• 依托单位: TECHNICAL RESOURCES INTERNATIONAL, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-27 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3626293
• 关键词: antineoplastics; bioassay; cancer information system; carcinogen testing; chemical carcinogen; chemical information system; chemical related neoplasm /cancer; cocarcinogen; environment related neoplasm /cancer; mutagen testing; occupational disease /disorder

This project provides a mechanism for the development of information in the areas of environmental and occupational cancer and consists of four tasks. Task I is used to support NCI's Division of Cancer Etiology's Chemical Selection Working Group in its effort to select and nominate chemicals to the National Toxicology Program for carcinogenicity bioassay. The Division of Cancer Etiology, NCI, has been, and will continue to be, the primary source for nomination of candidate chemicals. Under Task I, class studies (chemicals by use or structural class) are conducted. From such class studies and other sources (IARC monographs, ad hoc nominations, in vitro studies, etc.) chemicals are selected and summary sheets are prepared to permit systematic evaluation and selection of candidates by the Chemical Selection Working Group. Task II of this project supports the information needs of the International Agency for Research on Cancer (IARC) by providing information for inclusion in Sections 1 and 2 of the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. An average of three IARC working group meetings are held each year in Lyon, France, and a contractor representative is usually required to attend these meetings. Task III deals with the maintenance and updating of NCI's Chemical Carcinogenesis Research Information System (CCRIS). CCRIS is a scientifically evaluated and fully referenced data base containing carcinogenicity, tumor promotion, co-carcinogenicity, mutagenicity and, more recently, tumor inhibitor test results. Future expansion of this data base envisions the addition of an epidemiology file. This file is not intended to stand by itself but rather serve as a cross-linkage on specific compounds between the various files in CCRIS. Data to be included in CCRIS are evaluated by contractor, in consort with consultants, according to established criteria provided by NCI. CCRIS is resident and searchable in the National Library of Medicine's TOXNET system. Under Task IV, special studies have been prepared such as Speciesto-Species Comparison of Carcinogen Metabolism, Survey of Organic Drinking Water Contaminants, Inhibitors of Chemical Carcinogens, amongst others. To assure high quality of any state-of-the-art reports prepared under this task, such reports have been reviewed by consultants from within and outside the Federal government. Preparation of such reports will depend on availability of funding. Also under this task, the Bioassay Report Summary Handbook are being compiled and updated. This handbook now contains summaries of over 300 NCI/NTP Carcinogenesis Bioassay Technical Reports.

该项目提供了一种信息开发机制 环境和职业癌症领域，由四个部分组成 任务。 任务 I 用于支持 NCI 癌症病因学部门的 化学品选择工作组努力选择和提名 化学品国家毒理学计划的致癌性生物测定。 NCI 癌症病因学部门一直并将继续： 候选化学品提名的主要来源。 在任务 I 下， 进行类别研究（按用途或结构类别划分的化学品）。 从 此类研究和其他来源（IARC 专着、特别提名、 体外研究等）选择化学品并汇总表 准备好系统地评估和选择候选人 化学品选择工作组。 本项目任务二支持 国际癌症研究机构的信息需求 (IARC) 通过提供包含在第 1 节和第 2 节中的信息 IARC 关于人类致癌风险评估的专着。 一个 IARC 工作组会议平均每年在里昂举行 3 次， 法国，通常需要承包商代表出席 这些会议。 任务 III 涉及 NCI 的维护和更新 化学致癌研究信息系统（CCRIS）。 CCRIS 是一个 经过科学评估和充分参考的数据库，其中包含 致癌性、促癌性、共致癌性、致突变性和， 最近，肿瘤抑制剂测试结果。 未来的扩展 数据库设想添加流行病学文件。 这个文件是 并非旨在独立存在，而是作为交叉链接 CCRIS 中各个文件之间的特定化合物。需包含的数据 CCRIS 由承包商与顾问一起进行评估， 根据 NCI 提供的既定标准。 CCRIS 是居民并且 可在国家医学图书馆的 TOXNET 系统中搜索。 在下面 任务四，已准备好特别研究，例如“物种到物种” 致癌物代谢比较、有机饮用水调查 污染物、化学致癌物抑制剂等。 到 确保根据本标准编写的任何最新报告的高质量 任务，这些报告已经过内部和外部顾问的审查 联邦政府之外。 此类报告的准备将取决于 关于资金的可用性。 同样在这项任务下，生物测定报告 摘要手册正在编写和更新中。 现在这本手册 包含 300 多个 NCI/NTP 致癌生物测定技术摘要 报告。