FOLLOW UP OF THE ALPHA TOCOPHEROL, BETA CAROTENE LUNG

拟议的项目是1999年在芬兰发起的一个项目的继续。 1984年，作为美国国家癌症研究所和 芬兰国家公共卫生研究所。 主要活动是 α-生育酚β-胡萝卜素肺癌预防研究（ATBC研究）， 大型随机、双盲、安慰剂对照、2x2析因设计， 一级预防试验测试α-生育酚和β-生育酚的影响， 胡萝卜素补充剂对肺癌发病率和死亡率的影响。 本项目的主要目标是跟踪所有生活在 干预后ATBC研究的参与者（N= 24，000） （1994-2000年）继续监测干预措施对 肺癌和其他癌症以及其他发病率和死亡率终点。 是 用这些物质进行干预的效果将继续下去， 几年后，立即管理的积极 剂. 监测癌症发病率和死亡率， 在干预后阶段的非癌症原因将使我们能够确定 这些影响是否存在以及持续多久。 癌症发病率和所有 将在拟议的7年内确定死亡原因 期 计划定期与研究人群接触（第2年和第4年）。 5)这将允许收集更新的风险因素信息 包括一些受试者的额外生物样本。 另一个目的是研究现有的风险因素数据和生物学 癌症控制和因果关系假设的样本。 这些数据提供了一个 生物化学和分子假说研究的宝贵资源。 这种分析将在查明更多病例后提供更多信息 在后续的继续。 总之，ATBC研究是最大的肺癌化学预防试验， 曾经进行过。 经过PST 10年的开发和实施， 癌症预防研究的宝贵资源。 进一步的后续行动 这项干预研究的25,000名参与者是 在癌症预防领域具有不可否认的重要性。

The proposed project is a continuation of a project initiated in Finland in 1984 as a collaboration between the U.S. National Cancer Institute and the National Public Health Institute of Finland. The main activity been the Alpha-Tocopherol Beta-Carotene Lung Cancer Prevention Study (ATBC Study), a large randomized, double-blind, placebo-controlled, 2x2 factorial design, primary prevention trial testing the effects of alpha-tocopherol and beta- carotene supplements on lung cancer incidence and mortality. The primary objective of the present project is to follow all living participants in the ATBC Study (N=24,000) during the post-intervention period (1994-2000) to continue to monitor potential intervention effects on lung and other cancers and other morbidity and mortality endpoints. It is plausible that the effects of intervention with such agents will continue several years beyond the immediate period of administration of active agents. Monitoring cancer rates as well as morbidity and mortality from noncancer causes in the post-intervention period will allow us to determine if such effects exist and how long they last. Cancer incidence and all causes of mortality will be determined throughout the proposed 7-year period. Periodic contact with the study population is planned (years 2 and 5) which will permit collection of updated risk factor information including additional biologic specimens in some subjects. Another objective is to study the existing risk factor data and biologic samples for cancer control and causation hypotheses. These data provide an invaluable resource for the study of biochemical and molecular hypotheses. Such analyses will be more informative with the additional cases identified during the continued followup. In summary, the ATBC Study is the largest lung cancer chemoprevention trial ever conducted. Developed and implemented over the pst 10 years, it is an invaluable resource for cancer prevention research. Further follow-up of the 25,000 living participants from this intervention study is of undeniable importance in the field of cancer prevention.