FOLLOW UP OF THE ALPHA TOCOPHEROL, BETA CAROTENE LUNG

拟议的项目是#年在芬兰发起的一个项目的延续。 1984年是美国国家癌症研究所和 芬兰国家公共卫生研究所。主要活动是 α-生育酚-β-胡萝卜素肺癌预防研究(ATBC研究)， 一项大型随机、双盲、安慰剂对照、2x2析因设计， 初级预防试验测试α-生育酚和β-生育酚的效果 胡萝卜素补充剂对肺癌发病率和死亡率的影响。 本项目的主要目标是跟踪所有生物 干预后ATBC研究的参与者(N=24,000) 在此期间(1994-2000年)继续监测对 肺癌和其他癌症以及其他发病率和死亡率的终点。它是 这样的干预效果似乎还会持续下去 在Active的直接管理期之后几年 探员们。监测癌症发病率、发病率和死亡率 干预后时期的非癌症原因将使我们能够确定 如果这种影响存在，以及它们会持续多久。癌症发病率和ALL 死亡原因将在整个拟议的7年内确定 句号。计划与研究人群进行定期接触(第2年和 5)这将允许收集更新的风险因素信息 在一些科目中包括额外的生物标本。 另一个目标是研究现有的危险因素数据和生物学 癌症控制和因果关系假说的样本。这些数据提供了 生物化学和分子假说研究的宝贵资源。 随着发现的其他病例，这种分析将提供更多的信息 在继续跟进的过程中。 总而言之，ATBC研究是最大的肺癌化学预防试验 从未有过。在PST 10年的时间里开发和实施，它是一个 癌症预防研究的宝贵资源。进一步跟进 这项干预研究的25,000名活着的参与者是 在癌症预防领域具有不可否认的重要性。

The proposed project is a continuation of a project initiated in Finland in 1984 as a collaboration between the U.S. National Cancer Institute and the National Public Health Institute of Finland. The main activity been the Alpha-Tocopherol Beta-Carotene Lung Cancer Prevention Study (ATBC Study), a large randomized, double-blind, placebo-controlled, 2x2 factorial design, primary prevention trial testing the effects of alpha-tocopherol and beta- carotene supplements on lung cancer incidence and mortality. The primary objective of the present project is to follow all living participants in the ATBC Study (N=24,000) during the post-intervention period (1994-2000) to continue to monitor potential intervention effects on lung and other cancers and other morbidity and mortality endpoints. It is plausible that the effects of intervention with such agents will continue several years beyond the immediate period of administration of active agents. Monitoring cancer rates as well as morbidity and mortality from noncancer causes in the post-intervention period will allow us to determine if such effects exist and how long they last. Cancer incidence and all causes of mortality will be determined throughout the proposed 7-year period. Periodic contact with the study population is planned (years 2 and 5) which will permit collection of updated risk factor information including additional biologic specimens in some subjects. Another objective is to study the existing risk factor data and biologic samples for cancer control and causation hypotheses. These data provide an invaluable resource for the study of biochemical and molecular hypotheses. Such analyses will be more informative with the additional cases identified during the continued followup. In summary, the ATBC Study is the largest lung cancer chemoprevention trial ever conducted. Developed and implemented over the pst 10 years, it is an invaluable resource for cancer prevention research. Further follow-up of the 25,000 living participants from this intervention study is of undeniable importance in the field of cancer prevention.