INTERNATIONAL EPIDEMIOLOGY SURVEY OF HUMAN RETROVIRUSES

美国国家癌症研究所病毒流行病学分会负责 广泛的癌症和艾滋病病毒的流行病学研究 特别强调人类免疫缺陷病毒和其他 致癌逆转录病毒。其中许多病毒发生在海外地区。 例如人类T细胞淋巴营养病毒I和II。 拟议合同的目标将是支持研究 病毒流行病学部促进海外服务的使命 由病毒流行病学分会确定目标的研究项目 工作人员。这些研究通常在以下环境中进行：交流， 而接触研究人群的机会受到限制，因为他们在 非洲、亚洲和中南美洲的发展中国家。一个 拟议合同的主要目的将是支持这些研究 通过便利接触人口，安排与 当地医疗和政府卫生官员。另一个目标是 承包商要确保所有许可都是从 适当的机构审查委员会以确保所有要求 履行了研究风险保护办公室的职责。另一个 目标将是承包商执行研究方案 由病毒流行病学部工作人员发起，并确保特别 当地环境中的情况，如特殊后勤 关注的问题、文化敏感性等都得到了解决。主要目标 承包商实施海外现场工作的方式 确保收集的数据和样本具有最高质量 用于流行病学分析。另一个目标是承包商 为NCI提供病毒流行病学可以分析的数据 分支机构的研究结果将发表在同行评议期刊上。 总之，该项目的目标是开展一系列 不同地区人类逆转录病毒的流行病学研究 地点来回答有关这些和 癌症病因学中的其他致癌病毒。

The Viral Epidemiology Branch of the National Cancer Institute undertakes a broad range of epidemiologic studies of cancer and AIDS causing viruses with a particular emphasis on Human Immunodeficiency Virus and other oncogenic retroviruses. Many of these viruses occur in overseas locales such as the human T-cell lymphotrophic viruses type I and II. The objective of the proposed contract will be to support the research mission of the Viral Epidemiology Branch by facilitating overseas research projects whose goals are defined by Viral Epidemiology Branch staff. These studies often take place in settings where communications, and access to study populations are limited because they are in developing countries in Africa, Asia, and Central and South America. A major object of the proposed contract will be to supports these studies by facilitating access to populations, arranging for cooperation with local medical and governmental health officials. Another objective is for the contractor to insure that all clearances are obtained from appropriate Institutional Review Boards to insure that all requirements of the Office for Protection from Research Risk are fulfilled. Another objective will be for the contractor to implement research protocols originated by Viral Epidemiology Branch staff and insure that special circumstances in the local environment such as special logistical concerns, cultural sensitivities, etc are addressed. The major objective is for the contractor to implement overseas field work in a way that insures that the data and samples collected are of the highest quality for epidemiologic analysis. Another objective is for the contractor to supply NCI with data that can be analyzed by the Viral Epidemiology Branch with results of studies to be published in peer review journals. In summary the objective of this project is to conduct a series of epidemiologic studies of human retroviruses in different geographic locales to answer scientific questions concerning the role of these and other oncogenic viruses in the etiology of cancer.