INTERNATIONAL EPIDEMIOLOGY SURVEY OF HUMAN RETROVIRUSES

人类逆转录病毒国际流行病学调查

• 批准号: 2865324
• 负责人: HILLARY R KRUGER
• 金额: $ 11.01万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-03-01 至 1998-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2865324
• 关键词: Retroviridae; Retroviridae disease; blood banks; cancer risk; data collection methodology /evaluation; health science research support; health surveys; human tissue; medical records; neoplasm /cancer epidemiology; tissue resource /registry

The Viral Epidemiology Branch of the National Cancer Institute undertakes a broad range of epidemiologic studies of cancer and AIDS causing viruses with a particular emphasis on Human Immunodeficiency Virus and other oncogenic retroviruses. Many of these viruses occur in overseas locales such as the human T-cell lymphotrophic viruses type I and II. The objective of the proposed contract will be to support the research mission of the Viral Epidemiology Branch by facilitating overseas research projects whose goals are defined by Viral Epidemiology Branch staff. These studies often take place in settings where communications, and access to study populations are limited because they are in developing countries in Africa, Asia, and Central and South America. A major object of the proposed contract will be to supports these studies by facilitating access to populations, arranging for cooperation with local medical and governmental health officials. Another objective is for the contractor to insure that all clearances are obtained from appropriate Institutional Review Boards to insure that all requirements of the Office for Protection from Research Risk are fulfilled. Another objective will be for the contractor to implement research protocols originated by Viral Epidemiology Branch staff and insure that special circumstances in the local environment such as special logistical concerns, cultural sensitivities, etc are addressed. The major objective is for the contractor to implement overseas field work in a way that insures that the data and samples collected are of the highest quality for epidemiologic analysis. Another objective is for the contractor to supply NCI with data that can be analyzed by the Viral Epidemiology Branch with results of studies to be published in peer review journals. In summary the objective of this project is to conduct a series of epidemiologic studies of human retroviruses in different geographic locales to answer scientific questions concerning the role of these and other oncogenic viruses in the etiology of cancer.

美国国家癌症研究所病毒流行病学分支负责 对癌症和艾滋病病毒的广泛流行病学研究 特别强调艾滋病毒/艾滋病及其他 致癌逆转录病毒 其中许多病毒发生在海外地区 如I型和II型人类T细胞淋巴细胞病毒。 的 拟议合同的目的将是支持研究 病毒流行病学分支的使命， 目标由病毒流行病学分支确定的研究项目 工作人员 这些研究通常发生在通信， 和研究人群的接触是有限的，因为他们 非洲、亚洲和中南美洲的发展中国家。 一 拟议合同的主要目的是支持这些研究 为接触民众提供便利，安排与 当地医疗和政府卫生官员。 另一个目的是 承包商应确保所有间隙均来自 适当的机构审查委员会，以确保所有要求 保护研究风险办公室的要求得到了满足。 另一 承包商的目标是实施研究方案 由病毒流行病学分支工作人员发起， 当地环境的情况，如特殊的后勤 关注的问题、文化敏感性等得到解决。 主要目的 承包商在海外实地工作时， 确保收集的数据和样本具有最高质量 进行流行病学分析。 另一个目标是让承包商 为NCI提供病毒流行病学分析的数据 分支，研究结果将在同行评审期刊上发表。 总之，该项目的目标是开展一系列 不同地区人类逆转录病毒流行病学研究 地方来回答有关这些作用的科学问题， 其他致癌病毒在癌症病因学中的作用。

项目成果

Does umbilical cord blood polymerase chain reaction positivity indicate in utero (pre-labor) HIV infection?

脐带血聚合酶链反应阳性是否表明子宫内（临产前）感染艾滋病毒？

• DOI: 10.1097/00002030-199711000-00012
• 发表时间: 1997
• 期刊: AIDS (London, England)
• 作者: Biggar,RJ;Mtimavalye,L;Justesen,A;Broadhead,R;Miley,W;Waters,D;Goedert,JJ;Chiphangwi,JD;Taha,TE;Miotti,PG
• 通讯作者: Miotti,PG

Risk factors for human T cell lymphotropic virus type II infection among the Guaymi Indians of Panama.

巴拿马瓜伊米印第安人 II 型人类 T 细胞淋巴细胞病毒感染的危险因素。

• DOI: 10.1086/314916
• 发表时间: 1999
• 期刊: The Journal of infectious diseases
• 作者: Maloney,EM;Armien,B;Gracia,F;Castillo,L;Kruger,H;Levin,A;Levine,PH;Kaplan,JE;Blattner,WA;Giusti,RM
• 通讯作者: Giusti,RM

Genetic variability of human immunodeficiency virus type 1 in rural northwest Tanzania.

坦桑尼亚西北部农村地区 1 型人类免疫缺陷病毒的遗传变异。

• DOI: 10.1089/aid.1996.12.1389
• 发表时间: 1996
• 期刊: AIDS research and human retroviruses
• 影响因子: 1.5
• 作者: Robbins,KE;Bandea,CI;Levin,A;Goedert,JJ;Blattner,WA;Brubaker,G;Brown,TM;Schochetman,G;Kalish,ML;Shao,J;O'Brien,TR
• 通讯作者: O'Brien,TR