MIRA - MINOCYCLINE IN RHEUMATOID ARTHRITIS

这是一份研究合同，要建立一个临床中心参与 一项多中心、随机、双盲、安慰剂对照临床试验 一项将评估米诺环素治疗慢性阻塞性肺疾病疗效的试验 类风湿关节炎(RA)。拟议研究的目标是 确定米诺环素是否是治疗慢性粒细胞白血病的有效疗法 RA和确定不良反应的频率和严重程度 慢性米诺环素治疗类风湿关节炎。大约200个 类风湿关节炎患者将被随机分为积极治疗组， 会收到一颗含有100毫克的胶囊。一天两次的米诺环素和一个 对照组给予安慰剂胶囊，为期一年。初级阶段 结果的衡量标准将是关节肿胀和压痛的评估。

This is a research contract to established a clinical center to participate in a multicenter, randomized, double-blind, placebo controlled clinical trial that will assess the efficacy of minocycline in the treatment of rheumatoid arthritis (RA). The objectives of the proposed study are to determine whether minocycline is an effective therapy for the treatment of RA and to determine the frequency and severity of adverse effects of chronic minocycline therapy in patients with RA. Approximately 200 patients with RA will be randomized into an actively treated group that would receive a capsule containing 100 mg. of minocycline twice a day and a control group that would placebo capsules for one year. The primary measure of outcome will be an assessment of joint swelling and tenderness.