MIRA - 米诺环素治疗类风湿性关节炎-猫眼课题宝

MIRA - 米诺环素治疗类风湿性关节炎

批准号：

2298289

负责人：

DANIEL O CLEGG

金额：

$24.86万

依托单位：

UNIVERSITY OF UTAH

依托单位国家：

美国

项目类别：

财政年份：

1991

资助国家：

美国

项目状态：

已结题

起止时间：

1991-05-15 至 1994-04-14

来源：

https://reporter.nih.gov/project-details/2298289

关键词：

antiarthritic agent clinical trials drug adverse effect human subject human therapy evaluation rheumatoid arthritis skeletal disorder chemotherapy

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中文摘要

翻译

这是一份建立临床中心参与的研究合同

英文摘要

This is a research contract to established a clinical center to participate in a multicenter, randomized, double-blind, placebo controlled clinical trial that will assess the efficacy of minocycline in the treatment of rheumatoid arthritis (RA). The objectives of the proposed study are to determine whether minocycline is an effective therapy for the treatment of RA and to determine the frequency and severity of adverse effects of chronic minocycline therapy in patients with RA. Approximately 200 patients with RA will be randomized into an actively treated group that would receive a capsule containing 100 mg. of minocycline twice a day and a control group that would placebo capsules for one year. The primary measure of outcome will be an assessment of joint swelling and tenderness.

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