Sustainable Bioconversion of CO2 to Polyhydroxyalkanoates Biopolymer by Anaerobic Mixed Bacteria in a Single-Stage Gas Fermentation (CO2BIOPOL)

单阶段气体发酵中厌氧混合细菌将 CO2 可持续生物转化为聚羟基脂肪酸酯生物聚合物 (CO2BIOPOL)

• 批准号: EP/X021009/1
• 负责人: Sathiyanarayanan Ganesan
• 金额: $ 26万
• 依托单位: University of South Wales
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX021009%2F1
• 关键词: Sustainable; Bioconversion; CO2; Polyhydroxyalkanoates; Biopolymer

The increasing carbon dioxide (CO2) emissions are a significant contribution to global warming and climate change. The carbon capture and utilisation (CCU) strategy has emerged to convert the CO2 to carbon-based chemicals through gas fermentation to move towards a low-carbon economy. An interesting case for CCU is to produce intracellular biopolymers such as polyhydroxyalkanoates (PHA) from CO2 feedstock by anaerobic microorganisms. PHA holds several industrial and bulk applications, and it has been recognised as long-term sustainable green alternatives to petrochemical plastics since they are entirely biodegradable and biocompatible. This project is developing the concept of a novel biotech process for the sustainable bioconversion of CO2 into PHA by anaerobic mixed microbial cultures (MMC) via single-stage gas fermentation using novel high-rate gas transfer reactors. First, the project aims to investigate the appropriate anaerobic microbial communities for PHA synthesis. Secondly, intensification of PHA production conditions by selecting and controlling operating parameters along with PHA chain length elongation and medium-chain-length PHA synthesis by anaerobic MMC. Thirdly, optimised PHA production conditions will be evaluated under pilot-scale level along with cost-benefit analysis to demonstrate the sustainable long-term PHA production via single-stage gas fermentation. The proposed project is significant in terms of PHA production from renewable feedstocks (CO2) and would be an asset in the development of the bioeconomy within UK and European biotech industries. PHA production from CO2 would be an example of sustainable future clean technologies to save natural resources and energy.

二氧化碳（CO2）的增加是对全球变暖和气候变化的重要贡献。碳捕获和利用（CCU）策略已经出现，通过气体发酵将二氧化碳转换为基于碳的化学物质，以转向低碳经济。 CCU的一个有趣案例是通过厌氧微生物从CO2原料中产生细胞内生物聚合物，例如多羟基烷烃（PHA）。 PHA拥有几种工业和批量应用，并且被认为是石化塑料的长期可持续绿色替代品，因为它们完全可生物降解且具有生物相容性。该项目正在开发一种新型生物技术工艺的概念，该过程通过使用新型的高速气体转移反应器通过单阶段气体发酵，通过厌氧混合微生物培养物（MMC）通过厌氧混合微生物培养物（MMC）将CO2的可持续生物转化概念开发出来。首先，该项目旨在调查适当的厌氧微生物群落用于PHA合成。其次，通过选择和控制工作参数以及PHA链长度的伸长和中等链长度PHA合成，通过厌氧MMC来加强PHA生产条件。第三，优化的PHA生产条件将在试点规模级别以及成本效益分析下进行评估，以证明通过单阶段气体发酵的可持续长期PHA产生。拟议的项目在可再生原料（CO2）的PHA生产方面非常重要，并且将是英国和欧洲生物技术行业生物经济发展的资产。二氧化碳的PHA生产将是可持续的未来清洁技术，以节省自然资源和能源。