BioTrib-AVN: The effect of avascular necrosis of the hip on articular function in natural and artificial joints

BioTrib-AVN：髋关节股骨头缺血性坏死对天然关节和人工关节功能的影响

• 批准号: EP/X023532/1
• 负责人: Richard Hall
• 金额: $ 29.25万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX023532%2F1
• 关键词: BioTrib; AVN; effect; avascular; necrosis

The Postdoctoral Fellowship provides the opportunity for the applicant to undertake research and research training in one of Europe's foremost medical engineering research groups at the University of Leeds. The fellowship seeks to enhance the modelling approaches already developed by the applicant in bone remodelling with the advanced cartilage models being generated in Leeds to provide a key tool to mitigate the rising incidence of avascular necrosis (AVN) in Asia. AVN is a destructive disease, mainly found in the younger population, arising due to the disruption of blood supply to the femur head. It is the most common diagnosis (40%) for patients undergoing total hip replacement (THR) in Asia. Some patients may have the risk of collapse of the femoral head, depending upon the size of the lesion. Studies have observed a reduction in strength and stiffness in the pre-collapse stage of the AVN, which reduces the structural competence of the bone as well as the adjacent articular cartilage that covers the femoral head. Any disruption of the articular cartilage that arises from abnormal loading due to damage in the underlying bone has severe consequences for the overall joint function and ultimately pain and disability. The proposed research will investigate the link between AVN induced bone deterioration and joint function - biotribology - using a dynamic computational model that incorporates the evolution of the AVN from a bone function perspective. In the first instance, this will be an examination of the relationship between the cartilage function and bone properties in early stage AVN there are more conservative treatments. Such interventions are in urgent need of scientific underpinning; an aim that this model could achieve in the medium term. The second project, which will be delivered whilst on placement, will focus on late stage interventions for AVN, that is surface replacement where the design will be considered in terms of bone remodelling.

博士后奖学金为申请者提供了在利兹大学欧洲最重要的医学工程研究小组之一进行研究和研究培训的机会。该奖学金旨在加强申请者在骨重建方面已经开发的建模方法，利兹正在生成先进的软骨模型，以提供一个关键工具来缓解亚洲不断上升的缺血性坏死(AVN)发病率。AVN是一种破坏性疾病，主要发生在年轻人群中，由于股骨头的血液供应中断而引起。这是亚洲接受全髋关节置换(THR)患者最常见的诊断(40%)。有些患者可能有股骨头塌陷的风险，这取决于病变的大小。研究已经观察到AVN在塌陷前阶段的强度和刚度的降低，这降低了骨以及覆盖股骨头的邻近关节软骨的结构能力。由于下层骨的损伤而引起的异常负荷引起的关节软骨的任何破坏都会对整个关节功能造成严重的后果，并最终导致疼痛和残疾。这项拟议的研究将使用一个动态计算模型，从骨功能的角度结合AVN的演变来调查AVN引起的骨退化与关节功能(生物摩擦学)之间的联系。在第一种情况下，这将是一种检查软骨功能与骨性能之间的关系，在早期AVN有更多的保守治疗方法。这种干预措施迫切需要科学的支持；这是这种模式可以在中期内实现的目标。第二个项目将在植入的同时进行，将重点放在AVN的晚期干预上，即表面置换，其中设计将从骨重建的角度进行考虑。