BioTrib-AVN: The effect of avascular necrosis of the hip on articular function in natural and artificial joints

BioTrib-AVN:髋关节股骨头缺血性坏死对天然关节和人工关节功能的影响

基本信息

  • 批准号:
    EP/X023532/1
  • 负责人:
  • 金额:
    $ 29.25万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2022
  • 资助国家:
    英国
  • 起止时间:
    2022 至 无数据
  • 项目状态:
    未结题

项目摘要

The Postdoctoral Fellowship provides the opportunity for the applicant to undertake research and research training in one of Europe's foremost medical engineering research groups at the University of Leeds. The fellowship seeks to enhance the modelling approaches already developed by the applicant in bone remodelling with the advanced cartilage models being generated in Leeds to provide a key tool to mitigate the rising incidence of avascular necrosis (AVN) in Asia. AVN is a destructive disease, mainly found in the younger population, arising due to the disruption of blood supply to the femur head. It is the most common diagnosis (40%) for patients undergoing total hip replacement (THR) in Asia. Some patients may have the risk of collapse of the femoral head, depending upon the size of the lesion. Studies have observed a reduction in strength and stiffness in the pre-collapse stage of the AVN, which reduces the structural competence of the bone as well as the adjacent articular cartilage that covers the femoral head. Any disruption of the articular cartilage that arises from abnormal loading due to damage in the underlying bone has severe consequences for the overall joint function and ultimately pain and disability. The proposed research will investigate the link between AVN induced bone deterioration and joint function - biotribology - using a dynamic computational model that incorporates the evolution of the AVN from a bone function perspective. In the first instance, this will be an examination of the relationship between the cartilage function and bone properties in early stage AVN there are more conservative treatments. Such interventions are in urgent need of scientific underpinning; an aim that this model could achieve in the medium term. The second project, which will be delivered whilst on placement, will focus on late stage interventions for AVN, that is surface replacement where the design will be considered in terms of bone remodelling.
博士后奖学金为申请者提供了在利兹大学欧洲最重要的医学工程研究小组之一进行研究和研究培训的机会。该奖学金旨在加强申请者在骨重建方面已经开发的建模方法,利兹正在生成先进的软骨模型,以提供一个关键工具来缓解亚洲不断上升的缺血性坏死(AVN)发病率。AVN是一种破坏性疾病,主要发生在年轻人群中,由于股骨头的血液供应中断而引起。这是亚洲接受全髋关节置换(THR)患者最常见的诊断(40%)。有些患者可能有股骨头塌陷的风险,这取决于病变的大小。研究已经观察到AVN在塌陷前阶段的强度和刚度的降低,这降低了骨以及覆盖股骨头的邻近关节软骨的结构能力。由于下层骨的损伤而引起的异常负荷引起的关节软骨的任何破坏都会对整个关节功能造成严重的后果,并最终导致疼痛和残疾。这项拟议的研究将使用一个动态计算模型,从骨功能的角度结合AVN的演变来调查AVN引起的骨退化与关节功能(生物摩擦学)之间的联系。在第一种情况下,这将是一种检查软骨功能与骨性能之间的关系,在早期AVN有更多的保守治疗方法。这种干预措施迫切需要科学的支持;这是这种模式可以在中期内实现的目标。第二个项目将在植入的同时进行,将重点放在AVN的晚期干预上,即表面置换,其中设计将从骨重建的角度进行考虑。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Richard Hall其他文献

The Emotional Lives and Legacies of Fathers and Sons in Britain, 1945-1974
1945-1974 年英国父子的情感生活和遗产
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Richard Hall
  • 通讯作者:
    Richard Hall
Role of Helicobacter pylori Immunohistochemistry in the Histopathological Assessment of Inflamed Endoscopic Gastric Biopsies
幽门螺杆菌免疫组织化学在炎症内镜胃活检组织病理学评估中的作用
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    MBChB Alessandro Pietro Aldera;Richard Hall;Cassandra Bruce;Washington Mudini
  • 通讯作者:
    Washington Mudini
Impact of Khorana Score, Tumor Histology, and Treatment Regimen on VTE Incidence in Lung Cancer
  • DOI:
    10.1182/blood-2024-208970
  • 发表时间:
    2024-11-05
  • 期刊:
  • 影响因子:
  • 作者:
    Rishika Singh;Sean Dougherty;Nathan Roberts;Caleb Mckinney;Aditya Singh;Jack Masur;Wendy Novicoff;Richard Hall
  • 通讯作者:
    Richard Hall
PP01.135 Outcomes and Treatment Patterns for Recurrence following Concurrent Chemoradiation and Consolidation Immunotherapy in Unresectable Stage III NSCLC: A Multi-Center Study
PP01.135 不可切除 III 期非小细胞肺癌同步放化疗联合巩固免疫治疗后复发的结局和治疗模式:一项多中心研究
  • DOI:
    10.1016/j.jtho.2024.05.358
  • 发表时间:
    2024-07-01
  • 期刊:
  • 影响因子:
    20.800
  • 作者:
    Philip Young;John Sharp;Kenan Michaels;Kylie Fultineer;Richard Hall;Alia Lynch;Marie Thomas;Dwight Owen;Ryan Gentzler
  • 通讯作者:
    Ryan Gentzler
Connecting the dots…: information sharing by post-secondary educational institutions under the Family Education Rights and Privacy Act (FERPA)
连接点……:高等教育机构根据《家庭教育权利和隐私法》(FERPA) 进行信息共享
  • DOI:
    10.1080/09539960903450548
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Richard D. Graham;Richard Hall;W. Gerry Gilmer
  • 通讯作者:
    W. Gerry Gilmer

Richard Hall的其他文献

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{{ truncateString('Richard Hall', 18)}}的其他基金

International Centre of Excellence in the Treatment of Pathological Fractures
国际病理性骨折治疗卓越中心
  • 批准号:
    EP/Z531248/1
  • 财政年份:
    2024
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Research Grant
Oncological Engineering - A new concept in the treatment of bone metastases
肿瘤工程——治疗骨转移的新概念
  • 批准号:
    EP/W007096/2
  • 财政年份:
    2024
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Research Grant
Oncological Engineering - A new concept in the treatment of bone metastases
肿瘤工程——治疗骨转移的新概念
  • 批准号:
    EP/W007096/1
  • 财政年份:
    2022
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Research Grant
Developing Optimised Vertebroplasty Treatments for Vertebral Fractures in Multiple Myeloma
开发针对多发性骨髓瘤椎体骨折的优化椎体成形术治疗方法
  • 批准号:
    EP/H013385/1
  • 财政年份:
    2010
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research in Political Science: Inviting Outsiders In: Learning and Legitimation in Agency Policymaking
政治学博士论文研究:邀请局外人参与:机构决策中的学习和合法化
  • 批准号:
    0241406
  • 财政年份:
    2003
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research in Political Science: Out of Sight, Out of Mind: Legislators' Perceptions and Representation in Congress
政治学博士论文研究:眼不见心不烦:立法者的看法和国会代表
  • 批准号:
    0213959
  • 财政年份:
    2002
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Standard Grant
A Theoretical and Emperical Study of Legislative Lobbying Strategies
立法游说策略的理论与实证研究
  • 批准号:
    0004419
  • 财政年份:
    2001
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Standard Grant
Neurosciences in Undergraduate Physiology
本科生理学中的神经科学
  • 批准号:
    9750643
  • 财政年份:
    1997
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Standard Grant
Organized Interests and the Mobilization of Bias in Congress
有组织的利益和国会中偏见的动员
  • 批准号:
    9310247
  • 财政年份:
    1993
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Standard Grant
Research Initiation - Optimal Stimuli Distributions in Layered Structures Similar to Mammalian Visual System
研究启动 - 类似于哺乳动物视觉系统的分层结构中的最佳刺激分布
  • 批准号:
    7609885
  • 财政年份:
    1976
  • 资助金额:
    $ 29.25万
  • 项目类别:
    Standard Grant

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  • 批准号:
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