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Magnify - Creating the hyperpolarization battery to magnify NMR signals and improve analysis

Magnify - 创建超极化电池来放大 NMR 信号并改进分析

基本信息

批准号：
EP/X023672/1
负责人：
S Duckett
金额：
$ 329.98万
依托单位：
University of York
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FX023672%2F1
关键词：
Magnify Creating hyperpolarization battery magnify

项目摘要

Chemical analysis is integral to understanding materials and their production. Consequently, it is a key technology that underpinsEurope's chemical and pharmaceutical sectors. We seek here to change the way we analyse materials, biological processes, catalysisand reactivity using magnetic resonance (MR). This will involve creating the hyperpolarisation battery (HB) via parahydrogen, whosesubsequent discharge will magnify MR responses to facilitate previously impossible measurements.Through this lens, the low cost identification and quantification of molecules and their roles in catalysis will become possible. This willlead to faster analyses, improved catalysts and methods to transform chemicals manufacture thereby creating new commercialopportunities and improving research efficiency. Catalysis produces 80% of industrially relevant chemicals and pharmaceuticals, andaccounts for 20-30% of world gross domestic product. Europe is a leading player here, but this position needs strengthening toaddress challenges by China, the USA and Japan. Our methods also lie on the path to creating highly visible contrast agents forimproved disease diagnosis and treatment by MRI. The HB dovetails therefore with a need to support aging populations and addressconditions like cancer and neurodegenerative disorder.Creating a versatile HB will involve a synthetic programme, magnetic field analysis and detailed optimisation. We must define itschemical nature, optimise charging from parahydrogen gas and ensure its charged lifetime allows isolation from parahydrogen toovercome existing safety, solvent and selectivity limitations. Sensitisation through discharge of the isolated HB must broaden scopeto enable studies of catalysis, pharmaceutical preparations and potential MRI contrast agents. By breaking the link to parahydrogen,solvent and reaction diversity is assured; the now controllable properties of the HBs will define scope and the final hyperpolarisationoutcome.

化学分析是了解材料及其生产不可或缺的。因此，它是支撑欧洲化学和制药行业的关键技术。我们在这里寻求改变我们使用磁共振（MR）分析材料，生物过程，催化剂和反应性的方式。这将涉及到通过仲氢来制造超极化电池（HB），它的低温放电将放大MR响应，以促进以前不可能的测量。通过这种透镜，低成本的分子识别和定量及其在催化中的作用将成为可能。这将导致更快的分析，改进的催化剂和方法来改变化学品制造，从而创造新的商业机会并提高研究效率。催化生产80%的工业相关化学品和药品，占世界国内生产总值的20-30%。欧洲在这方面是一个领导者，但这一地位需要加强，以应对中国、美国和日本的挑战。我们的方法还在于创造高度可见的造影剂，以改善MRI的疾病诊断和治疗。因此，HB需要支持老龄化人口并解决癌症和神经退行性疾病等问题。创建多功能HB将涉及合成程序，磁场分析和详细优化。我们必须定义其化学性质，优化仲氢气体的充电，并确保其充电寿命允许从仲氢中分离，以克服现有的安全性，溶剂和选择性限制。通过放电的孤立HB敏化必须拓宽scope，使催化，药物制剂和潜在的MRI造影剂的研究。通过打破仲氢的联系，溶剂和反应的多样性得到了保证;现在可以控制的性质将确定范围和最终的超极化结果。