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Signal Amplification in NMR and MRI using hyperpolarised compounds

使用超极化化合物放大 NMR 和 MRI 中的信号

基本信息

批准号：
EP/H029575/1
负责人：
S Duckett
金额：
$ 9.75万
依托单位：
University of York
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH029575%2F1
关键词：
Signal Amplification NMR MRI using

项目摘要

The NMR Centre and the Neuroimaging Centre at the University of York have conducted a programme of work that has demonstrated that one of the fundamental limitations of conventional Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) techniques can be dramatically overcome. NMR is the most popular method for performing analytical and structural chemistry and MRI is the technique of choice for carrying out non-invasive imaging in humans. Even though the global markets for these techniques exceeds 6billion annually, as identified in a recent US report to Congress, both technologies are limited in application due to poor sensitivity. A process termed hyperpolarisation, developed in York throughout the last decade, allows these limitations to be overcome. We have recently shown that 0.5 seconds worth of data collection equates to 58 days on the conventional device.In laymen's terms, both NMR and MRI deal with the probing of the magnetic behaviour of nuclei within molecules. These nuclei behave like bar magnets and therefore can either have a north or south seeking orientation. Parahydrogen is simply a reaction feedstock where rather than having a mixture of such orientations, we start with a pure magnetic form. We have established a new route to utilising this feedstock in MR studies. The parahydrogen simply acts like a radiator which when brought into contact with its surroundings warms the room. In this case, the result is a potential 31,000 increase in detected signal strength. The information obtained through MIR studies is well established as providing critical information related to diagnosis and treatment in the health field. The breakthrough in sensitivity enhancement offers opportunities for a step change in modern healthcare and in high resolution NMR markets. This is achieved without the chemical modification of a material and it can employ substances that are native to the body. We therefore expect that it will not suffer from the toxicological problems associated with gadolinium contrast agents and PET and hence be well received by the medical community and laymen alike.Please see Proposal Form for details

约克大学的核磁共振中心和神经成像中心开展了一项工作方案，该方案表明，传统核磁共振和磁共振成像技术的一个基本局限性可以大大克服。NMR是进行分析和结构化学的最流行的方法，MRI是进行人体非侵入性成像的首选技术。尽管这些技术的全球市场每年超过60亿美元，正如美国最近向国会提交的一份报告所指出的那样，但由于灵敏度低，这两种技术的应用受到限制。在过去的十年中，约克开发了一种称为超极化的方法，可以克服这些限制。我们最近的研究表明，在传统设备上，0.5秒的数据收集相当于58天。通俗地说，NMR和MRI都是探测分子内原子核的磁性行为。这些原子核的行为就像条形磁铁，因此可以有向北或向南的取向。仲氢只是一种反应原料，我们从纯磁性形式开始，而不是具有这些取向的混合物。我们已经建立了一个新的路线，利用这种原料的MR研究。仲氢的作用就像一个散热器，当它与周围环境接触时，就会使房间变暖。在这种情况下，结果是检测到的信号强度可能增加31，000。通过MIR研究获得的信息被公认为提供了与卫生领域的诊断和治疗有关的关键信息。灵敏度增强方面的突破为现代医疗保健和高分辨率NMR市场的一步变化提供了机会。这是在没有材料的化学改性的情况下实现的，并且它可以使用身体固有的物质。因此，我们预计它不会受到与钆造影剂和PET相关的毒理学问题的影响，因此会受到医学界和非专业人士的欢迎。详情请参阅建议书

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Iridium(III) hydrido N-heterocyclic carbene-phosphine complexes as catalysts in magnetization transfer reactions.

DOI：
10.1021/ic401783c
发表时间：
2013-12-02
期刊：
Inorganic chemistry
影响因子：
4.6
作者：
Fekete M;Bayfield OW;Duckett SB;Hart S;Mewis RE;Pridmore N;Rayner PJ;Whitwood A
通讯作者：
Whitwood A

Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen.

DOI：
10.1039/c5sc00756a
发表时间：
2015-07-01
期刊：
Chemical science
影响因子：
8.4
作者：
Appleby KM;Mewis RE;Olaru AM;Green GGR;Fairlamb IJS;Duckett SB
通讯作者：
Duckett SB

Improving the hyperpolarization of (31)P nuclei by synthetic design.

通过合成设计改善（31）P核的超极化。

DOI：
10.1021/acs.jpcb.5b00686
发表时间：
2015-04-16
期刊：
JOURNAL OF PHYSICAL CHEMISTRY B
影响因子：
3.3
作者：
Burns, Michael J.;Rayner, Peter J.;Green, Gary G. R.;Highton, Louise A. R.;Mewis, Ryan E.;Duckett, Simon B.
通讯作者：
Duckett, Simon B.

Improving NMR and MRI sensitivity with parahydrogen.

使用仲氢提高 NMR 和 MRI 灵敏度。