PEDIATRIC AIDS CLINICAL TRIALS GROUP

我们建议在纽约市建立纽约儿科 上西区艾滋病临床试验单位联盟。 该联盟 由以下地点组成：婴儿医院、哈莱姆医院、 化身儿童中心（ICC）和圣卢克罗斯福 医院该联盟位于艾滋病毒的中心 流行病，并因此可以提供访问ACTG协议，以超过100 新感染艾滋病毒的妇女、婴儿和儿童。 PI和 每个机构的其他研究人员都是经验丰富的调查人员， 艾滋病临床试验，每个人都是全职教员在 哥伦比亚大学内外科医师学院。 它们提供 一个令人兴奋的人才和利益的组合，因为有些人是 儿科传染病专家和其他主要 护理医生。 不仅有ACTG认证的免疫学， 婴儿病毒学实验室，所有标本将被送往，但 还有一批已建立和独立资助的 对艾滋病毒基础研究感兴趣的研究人员，他们将 为发展新的方法提供临界质量 预防和治疗艾滋病毒感染。 婴儿医院 参与NIH支持的HIV病毒研究的工作人员的交织 女性向其后代传播（WITS）和ACTG临床 试验提供了一个独特的机会，患者从一个 艾滋病毒研究成为另一个，从而导致高水平的访问， 妇女和儿童在ACTU协议。 代表性患者 由财团医院服务的人口主要是 贫困、来自少数群体和社会弱势群体。 这 受艾滋病流行影响最严重的人口。联系经过严格 婴儿医院的专业三级护理设施提供 为其他艾滋病毒感染者人数众多的机构提供动力 妇女和儿童加入婴儿医院， 财团 在过去一年中，婴儿中心和国际刑事法院的工作人员 他们协同合作，招募了大量的 患者进入ACTU方案（儿科ACTG中的第二四分位数 1992年入学）。 联合体的成立将提供 更好地接触患者，出色的医疗水平 能力，以及基础研究人员与学术界的互动 从事ACTG临床试验的医生，这应该导致一个 在预防和预防艾滋病毒/艾滋病方面的研究成果很高， 治疗HIV感染。

We propose to establish, in New York City, The New York Pediatric Upper West Side AIDS Clinical Trials Unit Consortium. This Consortium is composed of the following sites: Babies Hospital, Harlem Hospital, Incarnation Children's Center (ICC), and St. Luke's Roosevelt Hospital. The Consortium is located in an epicenter of the HIV epidemic, and as such can provide access to ACTG protocols to over 100 new HIV-infected women, infants, and children per year. The PIs and other researchers at each institution are seasoned investigators in AIDS clinical trials, and each is a full time faculty member at the Columbia University College of Physicians and Surgeons. They provide a stimulating mix of talent and interests, in that some are specialists in Pediatric Infectious Diseases and others are Primary Care Physicians. There is not only an ACTG-certified immunology and virology laboratory at Babies to which all specimens will be sent, but there are also a group of established and independently funded investigators with interests in basic research on HIV, who will provide a critical mass for the development of new ideas in approaches to prevent and treat HIV infections. At Babies Hospital the interweaving of staff involved in NIH-supported HIV studies of viral transmission from women to their offspring (WITS) and in ACTG clinical trials provides a unique opportunity for rollover of patients from one HIV study into another, thus resulting in a high level of access to women and children in ACTU protocols. The representative patient population served by the hospitals of the Consortium is largely impoverished, from minority groups, and socially disadvantaged. This population is hardest hit by the AIDS epidemic. Access to highly specialized tertiary care facilities at Babies Hospital provides an impetus for the other institutions with large numbers of HIV-infected women and children to join with Babies Hospital to create the Consortium. For the past year, staff at the Babies site and at ICC have worked together synergistically to enroll a large number of patients into ACTU protocols (2nd quartile in Pediatric ACTG enrollment for 1992). Formation of the Consortium will provide greater access to patients, an outstanding level of medical competence, and interaction of basic researchers with academic physicians engaged in ACTG clinical trials, which should lead to a high degree of productivity in research on the prevention and treatment of HIV infection.