Training in Pediatric Infectious Disease

描述（由申请人提供）：本修订提案要求提供资金，以继续支持目前已有5年历史的儿科传染病培训计划。 这门学科在促进对发病机制、抗生素、抗病毒药、疫苗和其他抗感染药物在移植、恶性肿瘤化疗和新发感染中的理解方面非常重要，并确保该领域继续有新的发展。 该计划的目的是培养医学博士研究人员，他们已经接受过临床儿科学的培训，他们渴望从事研究，公共卫生和/或教学。 该计划是一个跨学科的，不仅涉及儿科系的讲师培训师，还涉及微生物学，解剖学和细胞生物学，流行病学，公共卫生，医学和免疫学系的讲师培训师。 在临床轮换期间，也将有机会获得临床试验以及医院微生物学，流行病学和感染控制方面的经验;然而，80%的培训将用于研究。 培训期为3-4年;每年需要3名博士后研究员。 哥伦比亚大学的广泛资源可供博士后研究员使用，包括由杰出演讲者举办的研讨会，以及在传染病学科接受过培训的经验丰富的儿科医生的教学和指导。 这些核心临床科学家已经与哥伦比亚的杰出基础科学家建立了联系，他们在研究项目中相互进行了广泛的合作。 这些科学家目前正在研究感染性生物体并研究疾病的分子发病机制;基础科学的观点为理解病原体逃避宿主防御并建立和继续感染的手段提供了强有力的见解。 儿科医生培训师的核心小组包括6名全职学术教师，他们都积极开展资金充足的研究项目，从基础科学到流行病学，疫苗开发，抗感染药物和疫苗的临床试验，以及医院感染控制。 这一培训补助金的更新将使我们能够继续一个培训计划，到目前为止，这所大学在过去5年中非常成功。

DESCRIPTION (provided by applicant): This revised proposal requests funding for continuation of support of the training program in Pediatric Infectious Diseases that is currently 5 years old. This discipline is important in promoting understanding of pathogenesis, antibiotics, antivirals, vaccines, and other anti-infectives in a setting of transplantation, chemotherapy for malignancy, and emerging infections, and assuring that there continue to be new developments in the field. The aim of the program is to develop MD investigators, who are already trained in Clinical Pediatrics, who aspire to a career in research, public health, and/or teaching. The program is an interdisciplinary one involving not only investigator-trainers in the Department of Pediatrics, but also those in the Departments of Microbiology, Anatomy and Cell Biology, Epidemiology, Public Health, Medicine and Immunology. There will also be an opportunity to gain experience in clinical trials as well as hospital microbiology, epidemiology and infection control during clinical rotations; however, 80% of training will be devoted to research. The period of training will be for 3-4 years; support for 3 Postdoctoral Fellows annually is being requested. Extensive resources at Columbia University are available to postdoctoral fellows, including seminars given by outstanding speakers, and teaching and mentoring from an experienced group of well-funded Pediatricians trained in the discipline of Infectious Diseases. These core clinician-scientists have already linked to distinguished basic scientists at Columbia and they collaborate extensively with each other in research projects. These scientists are currently investigating infectious organisms and examining the molecular pathogenesis of disease; the basic science perspective provides powerful insights into understanding the means by which pathogens evade host defenses and establish and continue infection. The core group of pediatrician-trainers includes 6 full-time academic faculty members, all actively carrying out well-funded research programs ranging from basic science to epidemiology, vaccine development, clinical trials of anti-infectives and vaccines, and hospital infection control. The renewal of this training grant will enable us to continue a training program that has so far been highly successful at this University during the past 5 years.