Tubular Supramolecular Polymer Brushes Delivery Vectors

管状超分子聚合物刷递送载体

• 批准号: EP/X025896/1
• 负责人: Sebastien Perrier
• 金额: $ 16.47万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX025896%2F1
• 关键词: Tubular; Supramolecular; Polymer; Brushes; Delivery

Nanostructures have emerged as key players in modern medicine in recent years, due to their numerous advantages employed as drug delivery vectors over conventional delivery systems, with applications ranging from contrast agents in medical imaging to gene delivery carriers to individual cells. In particular, research in nanoparticles (NPs) has explored how to make drugs more effective by having an in-depth understanding of the interaction of nanoparticles with cells, and the optimal toxicity or concentration. Compared to traditional drugs, enhanced pharmacokinetics, biocompatibility, tumour targeting, and stability are associated with NP-based drug delivery systems, while simultaneously playing an important role in minimizing systemic toxicity and overcoming drug resistance. However, many problems related to selective binding, targeted delivery and toxicity need to be overcome. In particular, the main challenge still remains achieving the correct balance safety / efficacy and improving the therapeutic index of a given drug. Once the NPs have delivered their payload, they must be engineered to degrade, to avoid organ accumulation, typically liver and spleen, causing toxicity and long-term health issues. This PoC application aims at addressing this issue, by building on the materials developed as part of the ERC Consolidator grant TUSUPO. These materials can effectively deliver anticancer drugs, have prolonged circulation time in vivo and eventually disassemble in non-toxic component which can be excreted. This project will expand the application of these materials and established their pharmacokinetic data, which are key to take them to clinic and market.

近年来，纳米结构已经成为现代医学中的关键参与者，因为它们作为药物传递载体比传统传递系统具有许多优点，应用范围从医学成像中的造影剂到基因传递载体到单个细胞。特别是，纳米粒子(NPs)的研究探索了如何通过深入了解纳米粒子与细胞的相互作用以及最佳毒性或浓度来提高药物的有效性。与传统药物相比，基于NP的药物释放系统具有更强的药代动力学、生物相容性、肿瘤靶向性和稳定性，同时在减少全身毒性和克服耐药性方面发挥着重要作用。然而，与选择性结合、靶向递送和毒性相关的许多问题需要克服。特别是，主要挑战仍然是实现安全性/有效性的正确平衡，并提高特定药物的治疗指数。一旦NPs交付了有效载荷，它们必须经过改造以降解，以避免器官堆积，尤其是肝脏和脾，从而导致毒性和长期健康问题。此PoC应用程序旨在通过利用作为ERC Consolidator Grate TUSUPO一部分开发的材料来解决这一问题。这些材料可以有效地输送抗癌药物，延长体内循环时间，最终以无毒成分的形式分解并可排出体外。本项目将扩大这些材料的应用范围，建立它们的药代动力学数据，这是将它们推向临床和市场的关键。

项目成果

Supra-Fluorophores: Ultrabright Fluorescent Supramolecular Assemblies Derived from Conventional Fluorophores in Water.

超荧光团：源自水中常规荧光团的超亮荧光超分子组装体。

• DOI: 10.1002/adma.202401346
• 发表时间: 2024
• 期刊: Advanced materials (Deerfield Beach, Fla.)
• 作者: Lei Y

Supra-Cyanines: Ultrabright Cyanine-Based Fluorescent Supramolecular Materials in Solution and in the Solid State

超花青：溶液和固态中的超亮花青基荧光超分子材料

• DOI: 10.1002/ange.202311224
• 发表时间: 2023
• 期刊: Angewandte Chemie
• 作者: Lu H

Modular design of cyclic peptide - polymer conjugate nanotubes for delivery and tunable release of anti-cancer drug compounds

用于抗癌药物化合物的递送和可调释放的环肽-聚合物缀合物纳米管的模块化设计

• DOI: 10.1016/j.jconrel.2024.01.023
• 发表时间: 2024
• 期刊: Journal of Controlled Release
• 影响因子: 10.8
• 作者: Hill S