CRYO-ROP VISUAL ACUITY CENTER

描述（研究者摘要） CRYO-ROP随访视力中心的目的是 在3例随访中实施视功能评估 参与多中心冷冻疗法的儿童组 早产儿视网膜病变（CRYO-ROP）研究。 第一组 由256名儿童组成，他们开发了5个连续或8个总时钟 3期早产儿视网膜病变（ROP）+疾病的时间， 是试验随机部分的参与者。第二 一组由67名儿童组成，即“特殊阈前”组， 在第3阶段ROP中开发少于5个连续或8个总时钟小时 加上疾病。这些小组将作为 11期CRYO-ROP随访研究。 第三组由 539名出生体重低于1000克的儿童， 23个研究中心。这些儿童没有发生ROP或不太严重的ROP 比其他两组的孩子要多， CRYO-ROP自然历史随访研究的结果。 所有三组的儿童都将接受单眼视觉评估， 视力、单眼对比敏感度、单眼色觉，以及 9岁时的立体视觉，以及单眼视力和 10岁时的单眼视野大小。 在随机和 特殊的阈值前组，评估将进行三个 前往当地中心的测试人员。这三个测试员加上两个 非旅行测试人员，将进行患者的评估， 自然历史组。 视力中心将培训测试人员使用评估方法 职能愿景，将监控测试人员的活动， 在23个中心测试随机和特殊阈值前患者， 五个中心的自然病史患者，将确保质量 保持控制，并将参与数据分析和编写 研究人群中与视觉功能相关的手稿。

DESCRIPTION (Investigator's Abstract) The purpose of the CRYO-ROP Follow-up Visual Acuity Center is to implement the assessment of visual function in the follow-up of three groups of children who were participants in the Multicenter Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) Study. The first group consists of 256 children who developed 5 contiguous or 8 total clock hours of stage 3 retinopathy of prematurity (ROP) with plus disease and were participants in the randomized portion of the trial. The second group consists of 67 children, the "special prethreshold" group, who developed fewer than 5 contiguous or 8 total clock hours of stage 3 ROP with plus disease. These groups will be followed as part of the Phase 11 CRYO-ROP Follow-up Study. The third group consists of 539 children with birth weights less than 1000g at five of the 23 study centers. These children developed no ROP or less severe ROP than children in the other two groups, and they will be followed as part of the CRYO-ROP Natural History Follow-up Study. Children in all three groups will receive assessments of monocular visual acuity, monocular contrast sensitivity, monocular color vision, and stereopsis at age 9 years, and assessments of monocular visual acuity and monocular visual field size at age 10 years. In the randomized and special prethreshold groups, assessments will be conducted by three Testers who travel to the local centers. These three Testers, plus two non-traveling testers, will conduct the assessments of the patients in natural history group. The Visual Acuity Center will train Testers in the methods used to assess functional vision, will monitor the activities of the Testers as they test randomized and special prethreshold patients in 23 centers and natural history patients in five centers, will assure that quality control is maintained, and will participate in data analysis and writing of manuscripts related to visual function in the study population.