CLINICAL ASSESSMENT OF VISUAL ACUITY IN HUMAN INFANTS

描述：(调查摘要)新生儿治疗中的婴儿 早产和/或围产期并发症的重症监护病房(NICU) 面临各种视觉障碍的风险，包括视力下降 视力、视野缩小、近视、斜视和视网膜病变 早产儿。我们目前的研究结果表明， 患有视网膜疾病的婴儿患视力障碍的风险最高。 与早产儿视网膜病变(ROP)或结构性相关的异常 脑部异常，如脑室周围白质软化症(PVL)， 严重(III级或IV级)脑室出血(IVH)，结构性 与足月新生儿缺氧/窒息相关的异常(FHA)。 拟议研究的目标是继续探索两者之间的关系 视力结果和围产期并发症之间的关系。三项研究 将开展以下项目：1)继续跟踪#年接受治疗的婴儿 新生儿重症监护室。24~48岁年龄段的光栅视力与视野发育 将对216名视力正常的儿童进行足月后年龄研究 在本赠款期间对发展进行了评估。测试将会 表明与以下因素相关的围产期并发症 婴儿期的视力或视野缺陷也会 与儿童早期的敏锐度和视野缺陷有关。2. 脑异常与视力关系的前瞻性研究 功能。将测量光栅敏锐度和视野的发展 在70名患有PVL、严重IVH或FHA的婴儿中，超声(US)， 计算机断层扫描(CT)和/或磁共振成像(MRI)扫描 他们的大脑是可用的。结构与功能的比较 在这一群体中的结果将表明， PVL婴儿的栅状视力和视野发育， 严重的IVH，或FHA与脑出血的部位、严重程度和程度有关 这些婴儿的大脑中存在结构性异常。3. 婴儿检测技术的验证和改进。 观察者间测验--视力的重测信度和预测效度 将对卡片程序进行评估。此外，一个 将开发电子控制的动态周长，并 合并周长所需的标准数据 将被收集到临床环境中。

DESCRIPTION: (Investigator's Abstract) Infants treated in the Neonatal Intensive Care Unit (NICU) for preterm birth and/or perinatal complications are at risk for a variety of visual disorders, including reduced visual acuity, reduced visual field size, myopia, strabismus, and retinopathy of prematurity. The results of our current study have revealed that the infants at highest risk for visual disorders are those who had retinal abnormalities related to retinopathy of prematurity (ROP) or structural abnormalities of the brain, such as periventriculr leukomalacia (PVL), severe (grade III or IV) intraventricular hemorrhage (IVH), and structural abnormalities related to hypoxia/asphyxia of the full-term neonate (FHA). The goal of the proposed research is to continue to explore the relation between visual outcome and perinatal complications. Three research projects will be undertaken: 1) Continued Follow-Up of Infants Treated in the NICU. Grating acuity and visual field development between 24 and 48 months post-term age will be studied in 216 children whose visual development was assessed during the current grant period. Testing will indicate whether the perinatal complications that were associated with visual acuity or visual field deficits during infancy will also be associated with acuity and field deficits in early childhood. 2. Prospective Study of the Relation Between Brain Abnormalities and Visual Function. Development of grating acuity and visual fields will be measured in 70 infants with PVL, severe IVH, or FHA, in whom ultrasound (US), computed tomography (CT), and/or magnetic resonance imaging (MRI) scans of their brains are available. Comparison of structural and functional results in this population will indicate whether the wide variation in grating acuity and visual field development found in infants with PVL, severe IVH, or FHA is related to the location, severity, and extent of structural abnormalities present in the brains of these infants. 3. Validation and Improvement of Testing Techniques for Infants. Interobserver test-retest reliability and predictive validity of the acuity card procedure will be evaluated. In addition, an electronically-controlled kinetic perimeter will be developed, and the normative data that are required for the incorporation of the perimeter into clinical settings will be collected.