WickedSchisto: Developing an robust interdisciplinary-informed WASH framework for the wicked public-health problem of schistosomiasis

WickedSchisto：针对血吸虫病这一邪恶的公共卫生问题，开发一个强大的跨学科 WASH 框架

• 批准号: EP/X027082/1
• 负责人: Poppy Lamberton
• 金额: $ 273.66万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX027082%2F1
• 关键词: WickedSchisto; Developing; robust; interdisciplinary; informed

Over 240 million people have schistosomiasis, a debilitating disease intrinsically linked to inadequate water, sanitation and hygiene (WASH). A wicked problem is a social or cultural problem that is difficult or impossible to solve. Despite extensive mass drug administration (MDA), schistosomiasis remains a wicked public-health problem. WASH-interventions are needed to reach the World Health Organization (WHO) 2030 goal of elimination as a public-health problem. Yet we don't understand the full impact of schistosomiasis, and therefore cannot identify what feasible and cost-effective WASH interventions best reduce this impact, nor the threats to long-term control programme success, and how to mitigate these. I will address five ambitious questions:1. What are the true health, economic and societal impacts of schistosomiasis?2. What are the most cost-effective combinations of WASH and MDA interventions?3. How best can we scale-up these public-health WASH interventions to reach WHO 2030 goals?4. What are the risks from human mobility to achieving and sustaining WHO 2030 goals?5. How can cross-sectorial policy buy-in be leveraged to help reach these goals?I will use innovative interdisciplinary methods to tackle this wicked public-health problem including: an unprecedented, bottom-up approach to identify acceptable, equitable, cost-effective, feasible, multifaceted interventions with highest 'value for money' and impact on schistosomiasis health-related quality of life; develop a field-based morbidity marker to monitor success; combine state-of-the-art parasite genomics with mathematical models to inform on control programme endpoints; and identify community, through to international level, facilitators to leverage for intervention success. My pioneering research will inform policymakers in Uganda and beyond on how best to eliminate schistosomiasis. I will fill a critical global-health knowledge gap and provide a framework for other WASH-associated diseases.

超过2.4亿人患有血吸虫病，这是一种与水、环境卫生和个人卫生不足有着内在联系的致残性疾病。一个邪恶的问题是一个社会或文化问题，很难或不可能解决。尽管有广泛的大规模药物管理（MDA），血吸虫病仍然是一个严重的公共卫生问题。需要WASH干预措施来实现世界卫生组织（WHO）2030年消除公共卫生问题的目标。然而，我们不了解血吸虫病的全部影响，因此无法确定哪些可行且具有成本效益的WASH干预措施最能减少这种影响，也无法确定对长期控制计划成功的威胁以及如何减轻这些威胁。我将回答五个雄心勃勃的问题：1。血吸虫病对健康、经济和社会的真正影响是什么？2. WASH和MDA干预措施的最具成本效益的组合是什么？3.我们如何才能最好地扩大这些公共卫生WASH干预措施，以实现世卫组织2030年目标？4.人员流动对实现和维持世卫组织2030年目标有哪些风险？5.如何利用跨部门的政策支持来帮助实现这些目标？我将使用创新的跨学科方法来解决这个邪恶的公共卫生问题，包括：一个前所未有的，自下而上的方法，以确定可接受的，公平的，具有成本效益的，可行的，多方面的干预措施，最高的“物有所值”和血吸虫病健康相关的生活质量的影响;开发一个基于实地的发病率标志，以监测成功;联合收割机将最先进的寄生虫基因组学与数学模型相结合，为控制方案终点提供信息;并确定社区直至国际一级的促进者，以促进干预成功。我的开创性研究将为乌干达及其他国家的政策制定者提供如何最好地消除血吸虫病的信息。我将填补一个关键的全球卫生知识空白，并为其他与WASH相关的疾病提供一个框架。