SCOR IN HEART FAILURE

心力衰竭专科研究中心(SCOR)是一个多学科、 跨部门临床和基础研究计划，旨在 减少因充血性心力衰竭而导致的死亡和残疾。这 建议的研究项目使用最先进的分子生物学 解决临床、药理学和生理学问题的技术 与心力衰竭患者的管理相关。临床部 该应用程序的组成部分包括对病理生理学的研究 充血性心力衰竭患者运动耐量的变化 失败了。基本组成部分包括对大多数 通过钙调变机制实现的基本生物过程 过度表达会导致心肌细胞肥大和增殖； α-肌动蛋白激活和脱敏的机制 肾上腺素能受体；腺苷受体介导的机制 血管平滑肌细胞的跨膜信号转导及其机制 门控和药物与瞬时外向钾通道的结合 在心脏复极中起重要作用。这一综合努力 旨在将申请者的各种研究结果转化为 在病理生理学、临床、药理学和 将外科治疗引入临床，以减少来自 充血性心力衰竭

Heart Failure Specialized Center of Research (SCOR) is a multidisciplinary, interdepartmental clinical and basic research program that is directed at the reduction of death and disability from congestive heart failure. This proposed research program uses state of the art molecular biological techniques to address clinical, pharmacological and physiological questions relevant to the management of heart failure patients. The clinical component of this application encompasses research into the pathophysiology of exercise intolerance in ambulatory patients with congestive heart failure. The fundamental component encompasses research into the most fundamental biological processes by the mechanism by which calmodulation overexpression causes cardiac myocyte hypertrophy and hyperplasia; the mechanisms underlying the activation and desensitization of alpha- adrenergic receptors; the mechanisms underlying adenosine receptor mediated transmembrane signalling in vascular smooth muscle cells; and the mechanism of gating and drug binding to a transient outward potassium channel that plays an important role in cardiac repolarization. This integrated effort is aimed at translating the results of the applicant's diverse research efforts concerning the pathophysiology, clinical, pharmacologic and surgical therapy into the clinic to reduce death and disability from congestive heart failure.