Cell-free synthetic biology for combinatorial biosensor design (SYNSENSO)

用于组合生物传感器设计的无细胞合成生物学 (SYNSENSO)

• 批准号: EP/X030792/1
• 负责人: Karen Polizzi
• 金额: $ 67.6万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX030792%2F1
• 关键词: Cell; free; synthetic; biology; combinatorial

Recent advances in the field of synthetic biology offer an unprecedented opportunity for next-generation biosensors characterized by programmability, low-cost and by a sensitivity and specificity unmet by conventional sensors. Leveraging the rich toolset of synthetic biology, we can now not only build better biosensors but also analytical tools that can sense and discern complex analyte profiles, such as a panel of biomarkers indicative of a certain disease status. These cell-free biosensors developed within the SYNSENSO research program will be transformative for many domains of research and innovation, ranging from in-vitro diagnostics to health, environmental and bioprocess monitoring. Our ambition is to provide a game change in biosensing by combining cell-free synthetic biology with molecular sensor design.The SYNSENSO European doctoral network focuses on the construction of novel programmable ligand-responsive elements and the construction of cell-free computing circuits that can integrate molecular signals from those elements. Together the two components will make up the next generation of combinatorial biosensors that can sense signals and compute a response to them. SYNSENSO aims for a modular approach where different responsive elements can be composed with different computing circuits enabling fast construction of suitable sensors for new application domains.SYNSENSO brings together academic and industry leaders from the fields of synthetic biology, molecular sensor design and DNA nanotechnology. Our industry partners will provide a unique ecosystem for ten doctoral candidates of this network. Together with the external advisory board including experts from medical diagnostics they will work on concrete case studies for clinically relevant analytes. The SYNSENSO training program will empower them to perform world-class research and become academic or industry leaders in this new emerging field at the intersection of synthetic biology and biosensors.

合成生物学领域的最新进展为下一代生物传感器提供了前所未有的机会，其特点是可编程、低成本以及传统传感器无法满足的灵敏度和特异性。利用合成生物学的丰富工具包，我们现在不仅可以制造更好的生物传感器，还可以制造能够感知和识别复杂分析物特征的分析工具，例如指示某种疾病状态的一组生物标志物。在SYNSENSO研究计划内开发的这些无细胞生物传感器将对许多研究和创新领域产生变革，从体外诊断到健康、环境和生物过程监测。我们的目标是通过将无细胞合成生物学与分子传感器设计相结合来改变生物传感的游戏规则。SYNSENSO欧洲博士网络专注于构建新型可编程配体响应元件，以及构建可以集成来自这些元件的分子信号的无细胞计算电路。这两个组件将共同组成下一代组合生物传感器，可以感知信号并计算对它们的响应。SYNSENSO致力于一种模块化的方法，不同的响应元件可以由不同的计算电路组成，从而能够快速构建适用于新应用领域的传感器。SYNSENSO汇集了合成生物学、分子传感器设计和DNA纳米技术领域的学术和行业领先者。我们的行业合作伙伴将为这个网络的十名博士生提供一个独特的生态系统。他们将与包括医学诊断学专家在内的外部咨询委员会一起，为临床相关的分析物开展具体的案例研究。SYNSENSO培训计划将使他们能够进行世界级的研究，并成为这一新兴领域的学术或行业领导者，该领域是合成生物学和生物传感器的交汇点。