THE MECHANISMS OF DECREASED ADHESION AND TRANSENDOTHELIAL MIGRATION

粘附力降低和跨内皮迁移的机制

• 批准号: 3740722
• 负责人: DIANE E LORANT
• 金额: --
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740722
• 关键词: biological signal transduction; cell adhesion; cell migration; human subject; neutrophil; newborn human (0-6 weeks); stimulant /agonist; vascular endothelium

The arrival of neonatal neutrophils to the site of infection is delayed compared to adult neutrophils, therefore, it appears that neutrophils from neonates are impaired in their ability to adhere to and respond to mediators of adhesion expressed on activated endothelial cells. Additionally, there may be a defect in regulated detachment of neonatal neutrophils that do adhere to stimulated endothelial cells and thus they may remain trapped in the lumen.

新生儿中性粒细胞到达感染部位的时间延迟 因此，与成人中性粒细胞相比， 新生儿的粘附和反应能力受损 活化内皮细胞上表达的粘附介质。 此外，新生儿的调节性脱离可能存在缺陷， 中性粒细胞粘附于刺激的内皮细胞，因此它们 可能仍然滞留在管腔中。