GNRH AGONIST STIMULATION TEST IN DISORDERS OF PUBERTAL PROGRESSION

青春期进展障碍的 GNRH 激动剂刺激试验

• 批准号: 3740353
• 负责人: ROBERT L. ROSENFIELD
• 金额: --
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740353
• 关键词: child (0-11); diagnosis quality /standard; diagnostic tests; endocrine disorder diagnosis; estradiol; follicle stimulating hormone; gonadotropin releasing factor; human subject; hypogonadism; luteinizing hormone; precocious puberty; stimulant /agonist; testosterone

We will study whether responses to the GnRH agonist nafarelin can distinguish among children with various disorders of gonadal function. Hypotheses will be tested to determine whether changes in serum concentrations of LH, FSH, estradiol, testosterone and biosynthetic intermediates after one injection of nafarelin can distinguish among different categories of patients diagnosed as hypogonadal or sexually precocious by independent tests.

我们将研究对GnRH激动剂纳伐林的反应是否可以