GNRH AGONIST TEST FOR GONADOTROPIN DEFICIENCY

促性腺激素缺乏症的 GNRH 激动剂测试

• 批准号: 3740392
• 负责人: ROBERT L. ROSENFIELD
• 金额: --
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740392
• 关键词: adolescence (12-20); diagnosis design /evaluation; endocrine disorder; endocrine disorder diagnosis; gonadotropin releasing factor; gonadotropins; human subject; hypogonadism; stimulant /agonist; young adult human (21-34)

We hypothesize that response to a single test done of GnRH agonist Lupron will distinguish between gonadotropin deficiency (GnD) and constitutional delay of puberty (CDP) better than sleep or GnRH (Factrol) tests. Secondary hypothesis: Optimally spaced series of Lupron injections will distinguish hypothalamic from pituitary causes of GnD. Pilot studies will be carried out in normal adult men & women 18-35 years of age. Major test pop. will be teenage boys & girls who are normal volunteers or have delayed puberty shown to be GnD or CDP.

我们假设对GnRH激动剂Lupron的单一测试的反应 将区分促性腺激素缺乏症（GnD）和体质性 青春期延迟（CDP）优于睡眠或GnRH（Factrol）测试。 次要假设：Lupron注射的最佳间隔系列将 区分GnD的下丘脑和垂体原因。试点研究将 在18-35岁的正常成年男性和女性中进行。重大考验 将是十几岁的男孩和女孩谁是正常的志愿者或有 青春期延迟显示为GnD或CDP。