ESTROGENIC PLANT COMPOUNDS AND ETIOLOGY OF BREAST CNACER

雌激素植物化合物和乳房癌的病因学

• 批准号: 3740312
• 负责人: BARRY GOLDIN
• 金额: --
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740312
• 关键词: breast neoplasms; cancer risk; chemoprevention; estrogens; female; human subject; plant extracts

The objective of this study is to determine if estrogens from plant sources can act anti-estrogenically in women and therefore lowering their estrogen load. A decreased estrogen exposure appears to lower the risk for breast cancer, (1/7000 th) relative to endogenous circulatory estrogens; however, these compounds bind estrogens receptors and therefore can block the action of circulatory estrogens, such as, estradiol.

本研究的目的是确定植物雌激素是否 来源可以发挥抗雌激素作用的妇女，因此降低其 雌激素负荷 减少雌激素暴露似乎可以降低风险 对于乳腺癌，（1/7000）相对于内源性循环 然而，这些化合物结合雌激素受体， 因此可以阻断循环雌激素的作用，例如， 雌二醇