Controlled clinical trial of desensitization to chronic pain

慢性疼痛脱敏对照临床试验

• 批准号: nhmrc : 465091
• 负责人: Prof Ann Louise Sharpe
• 金额: $ 23.28万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/controlled-clinical-trial-chronic-pain/77248
• 关键词: Controlled; clinical; trial; desensitization; chronic

An estimated 17.1% of males and 20.0% of females in NSW report having chronic pain. Chronic pain sufferers are major users of health services, with frequent medical consultations and high pharmacological consumption. A recent NSW population-based study found that 78% of pain sufferers had consulted at least one healthcare practitioner in the previous 6 months about their pain, and 71% of those sampled were taking regular oral analgesic medications. Disability due to chronic pain is often associated with higher levels of distress and use of healthcare services. Unfortunately, at present there are no lasting curative treatments for most chronic pain conditions and most people with these conditions are told they have to learn to live with their ongoing pain. One of the most effective ways of teaching chronic pain sufferers to live with their pain are known as cognitive behavioural therapy (CBT) interventions. But even though many find these methods helpful, a significant proportion of cases remain distressed by their pain. This places them at higher risk of relapse and further treatment seeking. If this group of pain sufferers could be taught more effective ways of minimising their pain-related distress, their overall functional and long-term quality of life goals could be maximised. The study has the potential to achieve a major improvement in outcomes for distressed patients with disabling chronic pain, traditionally a very intractable group. The study would also have important implications for the prevention of disability associated with persisting pain. If successful, it could alter the ways in which many health professionals advise patients to cope with their chronic pain, especially in relation to the use of the common modalities of relaxation and distraction techniques, as well as the use of pain reducing interventions. The study represents the first major clinical test of an alternative to these traditional modalities.

在新南威尔士州，估计有17.1%的男性和20.0%的女性报告有慢性疼痛。慢性疼痛患者是健康服务的主要使用者，就医频繁，药物消耗量高。新南威尔士州最近一项以人群为基础的研究发现，78%的疼痛患者在过去6个月内至少咨询过一名医疗从业者关于他们的疼痛，71%的抽样者正在服用常规的口服止痛药。慢性疼痛导致的残疾通常与更高水平的痛苦和对医疗服务的使用有关。不幸的是，目前大多数慢性疼痛还没有持久的治疗方法，大多数患有这些疾病的人被告知他们必须学会忍受持续的疼痛。教育慢性疼痛患者与疼痛共处的最有效方法之一是认知行为疗法(CBT)干预。但是，尽管许多人认为这些方法有帮助，但有相当大一部分病例仍然为自己的痛苦而苦恼。这使他们面临更高的复发风险和进一步寻求治疗的风险。如果这群疼痛患者能够学习到更有效的方法来最小化他们与疼痛相关的痛苦，他们的整体功能和长期生活质量目标可能会最大化。这项研究有可能使患有致残性慢性疼痛的痛苦患者的预后得到重大改善，而慢性疼痛传统上是一个非常棘手的群体。这项研究还将对预防与持续性疼痛相关的残疾具有重要意义。如果成功，它可能会改变许多卫生专业人员建议患者应对慢性疼痛的方式，特别是在使用常见的放松和分心技术方面，以及使用减轻疼痛的干预措施。这项研究是对这些传统模式的替代方案的第一次重大临床测试。