GENERAL CLINICAL RESEARCH CENTER

洛克菲勒大学综合临床研究中心（GCRC） 在实现洛克菲勒医院的目标中发挥核心作用： 将联合收割机实验室研究与床旁观察相结合， 为疾病检测、预防和治疗提供科学依据， 治疗GCRC提供了一个独特的环境，其理想的结构可以 在严格控制的条件下长期住院， 不仅研究患者的病理过程， 正常志愿者的生理过程。 重大，立即科学 目标包括：详细分析的相对影响 遗传因素与环境（饮食）因素相比， 改变血清脂质水平， 动脉粥样硬化和心脏病; 银屑病患者在不同治疗条件下的病变， 确定治疗的最佳方法;评估 通过改变细胞因子的作用获得的治疗益处 在急性炎症状态下-特别是沙利度胺的作用 对急性肺结核患者α-干扰素产生的影响;试验 基因治疗在缓解囊性癌症状中的疗效 纤维化;分析导致不良变化的生理事件 在老化过程中的蛋白质周转;量化能量的缺陷 体内平衡，导致肥胖的发展和维持， 男性;检查是否一个特定的神经内分泌异常是一个 不可避免的后果，有时是可卡因成瘾的先决条件; 评估细胞因子和免疫选择性元件的作用 系统在人类免疫缺陷病毒病发病机制中的作用， 为了确定施用特定细胞因子的治疗功效 在这种混乱中。 这些不同的问题，所有这些都有基本的 分子组成，以及需要详细的，有时 在我们的GCRC中进行长期临床观察， 非常适合临床研究培训中心的氛围。 大学和全球区域中心的新领导层特别强调 加强GCRC对医学生的培训， 容纳参谋人员和其他医生。

The Rockefeller University General Clinical Research Center (GCRC) plays a central role in fulfilling the objectives of The Rockefeller Hospital: to combine laboratory investigation with bed side observation in providing a scientific basis for disease detection, prevention and treatment. The GCRC provides a unique environment, ideally structured to conduct long hospitalizations under carefully controlled conditions for the study not only of pathologic processes in patients, but also of physiologic processes in normal volunteers. Major, immediate scientific objectives include: A detailed analysis of the relative effects of genetic factors as compared with environmental (dietary) factors in the modification of the levels of serum lipids that are fisk factors for atherosclerosis and heart disease; a histo-pathologic evaluation of the lesions of psoriatic patients under different conditions of treatment to determine the optimum method of treatment; an evaluation of the therapeutic benefits to be derived from modifying the action of cytokines in acute inflammatory states - specifically, the effect of thalidomide on alpha-interferon production in acute pulmonary tuberculosis; testing the efficacy of gene therapy in alleviating the symptoms of cystic fibrosis; analyzing the physiologic events which lead to adverse changes in protein turnover during aging; to quantify the defect in energy homeostasis that leads to the development and maintenance of obesity in man; to examine whether a specific neuroendocrine abnormality is an inevitable consequence and sometimes an antecedent of cocaine addiction; to evaluate the role of cytokines and selective elements of the immune system in the pathogenesis of human immunodeficiency virus disease and to determine the therapeutic efficacy of administering specific cytokines in that disorder. These varied problems, all of which have fundamental molecular components as well as a need for detailed and sometimes prolonged clinical observation in our GCRC, generate an intellectual atmosphere well suited for a training center in clinical research. New leadership of the University and the GCRC are giving special emphasis to strengthening this training aspect of the GCRC for medical students, house staff officers and other physicians.