GENERAL CLINICAL RESEARCH CENTER

洛克菲勒大学综合临床研究中心(GCRC) 在实现洛克菲勒医院的目标方面发挥核心作用： 实验室调查与床边观察相结合 为疾病检测、预防和管理提供科学依据 治疗。GCRC提供了一个独特的环境，理想的结构是 在严格控制的条件下进行长期住院治疗 这项研究不仅对患者的病理过程进行研究，而且对 正常志愿者的生理过程。重大的、直接的科学研究 目标包括：详细分析以下各项的相对影响 遗传因素与环境(饮食)因素的比较 作为FISK因子的血脂水平的改变 动脉粥样硬化与心脏病；组织病理学评价 银屑病患者皮损在不同治疗条件下的变化 确定最佳治疗方法；对 通过改变细胞因子的作用而获得的治疗益处 在急性炎症状态下--特别是沙利度胺的作用 急性肺结核病中α-干扰素的产生.检测 基因治疗在缓解囊性疾病症状中的作用 纤维化；分析导致不良变化的生理事件 在衰老过程中蛋白质的周转率；量化能量的缺陷 导致肥胖发生和维持的动态平衡 检查特定的神经内分泌异常是否为 可卡因成瘾的必然后果，有时甚至是前兆； 评价细胞因子和免疫选择性元件的作用 系统在人类免疫缺陷病毒病的发病机制中的作用 确定给予特定细胞因子的治疗效果 在这种混乱中。这些各种各样的问题，所有这些都有根本的 分子组成以及需要详细和有时 在我们的GCRC进行了长期的临床观察，产生了一个知识分子 非常适合临床研究培训中心的氛围。 大学和GCRC的新领导层特别强调 为了加强GCRC对医学生的这方面的培训， 众议院参谋人员和其他医生。

The Rockefeller University General Clinical Research Center (GCRC) plays a central role in fulfilling the objectives of The Rockefeller Hospital: to combine laboratory investigation with bed side observation in providing a scientific basis for disease detection, prevention and treatment. The GCRC provides a unique environment, ideally structured to conduct long hospitalizations under carefully controlled conditions for the study not only of pathologic processes in patients, but also of physiologic processes in normal volunteers. Major, immediate scientific objectives include: A detailed analysis of the relative effects of genetic factors as compared with environmental (dietary) factors in the modification of the levels of serum lipids that are fisk factors for atherosclerosis and heart disease; a histo-pathologic evaluation of the lesions of psoriatic patients under different conditions of treatment to determine the optimum method of treatment; an evaluation of the therapeutic benefits to be derived from modifying the action of cytokines in acute inflammatory states - specifically, the effect of thalidomide on alpha-interferon production in acute pulmonary tuberculosis; testing the efficacy of gene therapy in alleviating the symptoms of cystic fibrosis; analyzing the physiologic events which lead to adverse changes in protein turnover during aging; to quantify the defect in energy homeostasis that leads to the development and maintenance of obesity in man; to examine whether a specific neuroendocrine abnormality is an inevitable consequence and sometimes an antecedent of cocaine addiction; to evaluate the role of cytokines and selective elements of the immune system in the pathogenesis of human immunodeficiency virus disease and to determine the therapeutic efficacy of administering specific cytokines in that disorder. These varied problems, all of which have fundamental molecular components as well as a need for detailed and sometimes prolonged clinical observation in our GCRC, generate an intellectual atmosphere well suited for a training center in clinical research. New leadership of the University and the GCRC are giving special emphasis to strengthening this training aspect of the GCRC for medical students, house staff officers and other physicians.