GENE THERAPY FOR TUMORS USING ANTISENSE CDNA TRANSCRIPTION GROWTH FACTOR I

使用反义 CDNA 转录生长因子 I 进行肿瘤基因治疗

• 批准号: 3741194
• 负责人: JOSEPH ILAN
• 金额: --
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3741194
• 关键词: antisense nucleic acid; drug screening /evaluation; gene therapy; glia; glioblastoma multiforme; growth factor; human subject; human therapy evaluation; tissue /cell culture; transcription factor; transfection

This study represents a treatment approach based on an antisense gene therapy strategy for otherwise incurable malignant human brain tumors. The specific aims are (1) to demonstrate the safety of subcutaneous injection of autologous in-vitro cultured, transfected and irradiate glial tumor cells from patients with glioblastoma multiforme and (2) to demonstrate the efficacy of injection of autologous in-vitro cultured and transfected glial tumor cells in destruction of native tumor.

这项研究代表了一种基于反义基因的治疗方法 其他无法治愈的恶性人脑肿瘤的治疗策略。 具体目标是（1）证明皮下注射的安全性 注射自体体外培养、转染、照射 来自多形性胶质母细胞瘤患者的神经胶质肿瘤细胞和（2） 证明注射自体体外培养和 转染的神经胶质肿瘤细胞破坏天然肿瘤。