GENE THERAPY FOR TUMORS USING ANTISENSE CDNA TRANSCRIPTION GROWTH FACTOR I

这项研究代表了一种基于反义基因的治疗方法， 治疗策略，否则无法治愈的恶性人脑肿瘤。 具体目的是（1）证明皮下注射的安全性 注射自体体外培养、转染和照射 来自多形性胶质母细胞瘤患者的胶质肿瘤细胞，和（2） 证明注射自体体外培养的和 转染的胶质瘤细胞破坏天然肿瘤。

This study represents a treatment approach based on an antisense gene therapy strategy for otherwise incurable malignant human brain tumors. The specific aims are (1) to demonstrate the safety of subcutaneous injection of autologous in-vitro cultured, transfected and irradiate glial tumor cells from patients with glioblastoma multiforme and (2) to demonstrate the efficacy of injection of autologous in-vitro cultured and transfected glial tumor cells in destruction of native tumor.