GENE THERAPY FOR BRAIN TUMORS USING ANTISENSE CDNA TRANSCRIPTION GROW

这项研究代表了一种基于反义基因治疗策略的治疗方法，用于治疗其他无法治愈的恶性人脑肿瘤。具体目的是（1）证明皮下注射来自多形性胶质母细胞瘤患者的自体体外培养、转染和辐照的胶质肿瘤细胞的安全性和（2）证明注射自体体外培养和转染的胶质肿瘤细胞在破坏天然肿瘤中的疗效。

This study represents a treatment approach based on an antisense gene therapy strategy for otherwise incurable malignant human brain tumors. The specific aims are (1) to demonstrate the safety of subcutaneous injection of autologous in-vitro cultured, transfected and irradiated glial tumor cells from patients with glioblastoma multiforme and (2) to demonstrate the efficacy of injection of autologous in-vitro cultured and transfected glial tumor cells in destruction of native tumor.