PHARMACOGENETICS OF ALFENTANIL METABOLISM & CORRELATION WITH CYTOCHROME P450IIIA

阿芬太尼代谢的药物遗传学

• 批准号: 3741414
• 负责人: ALASTAIR JJ WOOD
• 金额: --
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3741414
• 关键词: analog; anesthesiology; breath tests; cytochrome P450; drug metabolism; enzyme activity; fentanyl; human subject; isozymes; pharmacogenetics

Determine the pharmacogenetics of alfentanil metabolism with particular reference to cytochrome P450IIIA activity, and to determine the correlation of alfentanil pharmacokinetics with the activity of P45OIIIA4, reflected by the C14-erythromycin breath test determined in a separate protocol.

确定阿芬太尼代谢的药物遗传学， 参考细胞色素P450 IIIA活性，并确定 阿芬太尼药代动力学与活性的相关性 P45 OIIIA 4，通过C14-红霉素呼气试验反映， 一个单独的协议。