FACTORS AFFECTING INTERINDIVIDUAL RESPONSIVENESS TO DRUGS

影响个体间药物反应的因素

• 批准号: 3763594
• 负责人: ALASTAIR JJ WOOD
• 金额: --
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3763594
• 关键词: drug adverse effect; drug metabolism; genetic disorder; human old age (65+); human subject; inborn metabolism disorder; pharmacokinetics

To test the hypothesis that elderly subjects that have genetic deficiency in one route of metabolism are at particular risk for concentration dependent adverse effects due to a further age dependent loss of drug metabolizing ability in an alternative pathway.

为了验证一个假设，即有遗传缺陷的老年人 在一种代谢途径中， 由于药物的进一步年龄依赖性损失而导致的依赖性不良反应 代谢能力的替代途径。