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LIVER BIOPSY ASSOCIATED WITH CHOLECYSTECTOMY IN A SINGLE PATIENT

LIVER BIOPSY ASSOCIATED WITH CHOLECYSTECTOMY IN A SINGLE PATIENT
单个患者与胆囊切除术相关的肝活检
批准号：
3741298
负责人：
STEPHEN YOUNG
金额：
$0.0万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3741298
关键词：
abetalipoproteinemias apolipoproteins biopsy blood lipoprotein biosynthesis cholecystectomy familial hypolipoproteinemia gene mutation human subject liver cells liver metabolism messenger RNA radiotracer tissue /cell culture

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英文摘要
Hepatocytes will be obtained from a liver biopsy specimen at the time of an elective cholecystectomy to analyze the relative levels of mutant and normal apolipoprotein B mRNA levels in the hepatocytes of a single individual who is heterozygous for familial hypobetalipoproteinemia. The relative rates of synthesis of the truncated (mutant) apo-B protein and the full-length apo-B protein will also be determined by 35S metabolic labeling studies in cultured hepatocytes.
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