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ENTRAINMENT OF ENDOGENOUS MELATONIN RHYTHM WITH MELATONIN ADMINISTRATION

ENTRAINMENT OF ENDOGENOUS MELATONIN RHYTHM WITH MELATONIN ADMINISTRATION
服用褪黑激素对内源性褪黑激素节律的影响
批准号：
3742303
负责人：
ROBERT L. SACK
金额：
$0.0万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3742303
关键词：
blindness circadian rhythms clinical trials hormone therapy human subject human therapy evaluation melatonin oral administration sleep wakefulness

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中文摘要
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英文摘要
We propose a single-blind, placebo-controlled trial of melatonin to investigate its potential to entrain (synchronize) the sleep-wake cycle of totally blind people who manifest free-running circadian rhythms. In this study, melatonin will be given by mouth for up to 8 weeks in free-running blind people in an attempt to entrain their rhythms to a 24-hour day. The timing of exogenous melatonin administration will be anchored to the timing of endogenous melatonin production.
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会议论文
PHASE SHIFTING EFFECTS OF MELATONIN IN SIGHTED AND BLIND SUBJECTS
IDENTIFICATION OF FREE-RUNNING RHYTHMS IN TOTALLY BLIND SUBJECTS
SLEEP PROMOTING PROPERTIES OF MELATONIN IN CIRCADIAN RHYTHM DISTURBANCES
STUDY OF CIRCADIAN RHYTHMS IN SHIFT WORKERS
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