BIOAVAILABILITY, DISSOLUTION, SORPTION, AND NOXICITY OF NAPL

非水相有机液体是一种广泛存在的污染物 地下土壤和地下水。从人类健康的角度来看，这些 有机液体特别值得关注，因为它们往往代表 长期污染源，创造多样和持久的途径 以备最终的人类接触。本项目拟开展的工作有 旨在调查影响人类健康的过程 阿司匹林的包封性、持久性、转运、生物利用度和毒性 自然地下环境中的有机液体成分。它 代表一个基础研究计划，该计划建立在以前和 目前由NIEHS资助的项目，并将实验室和数学 模拟调查。这个项目关注的是行为和 复杂多环芳烃(PAH)混合物的毒性它的 具体目标与成分影响的量化有关 关于相平衡、传质动力学和生物转化，以及 对天然药物吸附过程和生物利用度的探索 媒体。与其他项目调查人员通过 产品评估核心将促进对表观遗传学的评估 生物转化前后多环芳烃混合物的毒性。因此， 所提出的工作旨在对所获得的知识进行逻辑扩展 在以往NIEHS资助的项目中考虑多个因素的相互作用 过程中，化学和物理异质性对 这些过程，以及复杂的NAPL混合物的行为和命运。 尽管主要针对的是自然发生的 衰减过程，从这些研究中获得的知识将具有 直接应用于设计更有效的补救措施 战略。

Nonaqueous phase organic liquids are widespread contaminants of subsurface soils and groundwater. From a human health perspective, these organic liquids are of particular concern because they tend to represent long-term sources of pollution and create diverse and persistent pathways for eventual human exposure. The work proposed in this Project is directed towards the investigation of processes which influence the entrapment, persistence, transport, bioavailability, and toxicity of organic liquid components in the natural subsurface environment. It represents a fundamental research program which builds upon previous and current NIEHS-funded projects and integrates laboratory and mathematical modeling investigations. This project focuses on the behavior and toxicity of complex polycyclic aromatic hydrocarbon (PAH) mixtures. Its specific aims relate to the quantification of compositional influences on phase equilibria, mass transfer kinetics, and biotransformations, and to the exploration of sorption processes and bioavailability in natural media. Collaboration with other project investigators through the Products Evaluation Core will facilitate the assessment of the epigenetic toxicity of PAH mixture prior and subsequent to biotransformation. Thus, the work proposed is designed to logically extend the knowledge gained in previous NIEHS-funded projects to consider the interaction of multiple processes, the influence of chemical and physical heterogeneities on these processes, and the behavior and fate of complex NAPL mixtures. Although directed primarily at the investigation of naturally occurring attenuation processes, the knowledge gained from these studies will have immediate applications to the design of more effective remediation strategies.