BIOAVAILABILITY, DISSOLUTION, SORPTION, AND NOXICITY OF NAPL

非水相有机液体是水的广泛污染物， 地下土壤和地下水。 从人类健康的角度来看， 有机液体特别令人关注，因为它们往往代表 长期的污染源，并创造多样化和持久的途径 最终暴露在人体内 本项目拟开展的工作是 旨在调查影响环境的过程 包封、持久性、转运、生物利用度和毒性 天然地下环境中的有机液体成分。 它 代表了一个基础研究计划，建立在以前的基础上， 目前NIEHS资助的项目，并整合了实验室和数学 模拟调查。 这个项目的重点是行为和 复杂多环芳烃（PAH）混合物的毒性。 其 具体目标涉及成分影响的量化 相平衡、传质动力学和生物转化， 探索自然界中的吸附过程和生物利用度， 媒体 与其他项目调查人员合作， 产品评价核心将有助于评估表观遗传 PAH混合物生物转化前后的毒性。 因此，在本发明中， 所提出的工作旨在逻辑地扩展所获得的知识 在以前的NIEHS资助的项目中， 化学和物理不均匀性对生产过程的影响 这些过程，以及复杂的NAPL混合物的行为和命运。 虽然主要是针对自然发生的调查 衰减过程，从这些研究中获得的知识将有 立即应用于设计更有效的补救措施 战略布局

Nonaqueous phase organic liquids are widespread contaminants of subsurface soils and groundwater. From a human health perspective, these organic liquids are of particular concern because they tend to represent long-term sources of pollution and create diverse and persistent pathways for eventual human exposure. The work proposed in this Project is directed towards the investigation of processes which influence the entrapment, persistence, transport, bioavailability, and toxicity of organic liquid components in the natural subsurface environment. It represents a fundamental research program which builds upon previous and current NIEHS-funded projects and integrates laboratory and mathematical modeling investigations. This project focuses on the behavior and toxicity of complex polycyclic aromatic hydrocarbon (PAH) mixtures. Its specific aims relate to the quantification of compositional influences on phase equilibria, mass transfer kinetics, and biotransformations, and to the exploration of sorption processes and bioavailability in natural media. Collaboration with other project investigators through the Products Evaluation Core will facilitate the assessment of the epigenetic toxicity of PAH mixture prior and subsequent to biotransformation. Thus, the work proposed is designed to logically extend the knowledge gained in previous NIEHS-funded projects to consider the interaction of multiple processes, the influence of chemical and physical heterogeneities on these processes, and the behavior and fate of complex NAPL mixtures. Although directed primarily at the investigation of naturally occurring attenuation processes, the knowledge gained from these studies will have immediate applications to the design of more effective remediation strategies.