SDZ ILS 969 WITH MAID CHEMOTHERAPY IN PATIENTS WITH NO PRIOR THERAPY FOR SARCOMA

SDZ ILS 969 对既往未接受过肉瘤治疗的患者进行辅助化疗

• 批准号: 3743130
• 负责人: MICHAEL S GORDON
• 金额: --
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3743130
• 关键词: MESNA; antineoplastics; chemoprevention; combination chemotherapy; computed axial tomography; dacarbazine; detoxification; doxorubicin; electrocardiography; human subject; human therapy evaluation; ifosfamide; interleukin 6; neoplasm /cancer immunotherapy; neoplasm /cancer therapy; sarcoma

Chemotherapy from a combination of Adriamycin with the drugs ifosfamide and decarbazine (DTIC). An additional drug, mesna is used to protect the bladder's lining. Groups of 4 patients will be treated to higher doses of rhlL-6. Bloods and urine will be taken and EKGs. PFTs, CXRs, and CTs will be used to monitor the effects of chemotherapy and the strength of patients' hearts.

阿霉素与异环磷酰胺联合化疗 和去卡巴肼(DTIC)。另一种药物梅斯纳被用来保护 膀胱的衬里。4名患者将接受更大剂量的治疗 RH1L-6。将采集血液和尿液，并进行心电图。PFT、CXR和CT 将被用来监测化疗的效果和 病人的心脏。