ANABOLIC EFFECT OF GROWTH HORMONE IN INBORN ERRORS OF METABOLISM

生长激素对先天性代谢缺陷的合成代谢作用

• 批准号: 3743275
• 负责人: DEBORAH L MARSDEN
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3743275
• 关键词: alanine; bone density; child (0-11); child physical development; diet therapy; dietary supplements; hormone therapy; human subject; human therapy evaluation; inborn metabolism disorder; metabolism disorder chemotherapy; muscle disorders; nutrition related tag; osteoporosis; somatotropin

To establish whether growth hormone or alanine supplementation will improve linear growth or rates of increase in weight or head circumference in patients with inborn errors of metabolism requiring diets severely restricted in protein or in patients with glycogen storage disease, whether treatment can decrease catabolic production of toxic metabolites, whether myopathy is reduced and to assess effects on bone density to ameiorate osteoporosis.

为了确定生长激素或丙氨酸补充剂是否会 改善体重或头数线性增长或增长率 先天性代谢缺陷患者的围度 蛋白质严重受限或糖原蓄积患者的饮食 疾病，治疗是否可以减少有毒物质的分解代谢产生 代谢物，是否减少肌病，并评估对骨的影响 骨质疏松症的治疗。