BONE DENSITY IN CHILDREN W/ INBORN ERRORS OF METABOLISM ON SPECIAL DIETS

特殊饮食导致先天性代谢缺陷儿童的骨密度

• 批准号: 7380720
• 负责人: DEBORAH L MARSDEN
• 金额: $ 0.3万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380720
• 关键词: BONE; DENSITY; CHILDREN; INBORN; ERRORS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Aim 1: To determine whether patients with inborn errors of metabolism (IEM) have a decreased bone density when compared to healthy population controls. Secondary Aim 2: to determine wether bone density varies among the different types of IEM. (Phenylketonuria, homocystinuria, galactosemia, and organic acidemias). Aim 3: To examine factors associated with lower bone density among patients with IEM. Specifically, we will examine whether compliance with dietary restrictions, level of physical activity onset of, menses, hormonal levels, and micronurishment levels are associated with bone density.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。主要目的1：确定与健康人群对照相比，先天性代谢错误（IEM）患者的骨密度是否降低。次要目的2：确定不同类型IEM的骨密度是否不同。（苯丙酮尿、同型半胱氨酸尿、半乳糖血症和有机酸血症）。目的3：研究与IEM患者骨密度降低相关的因素。具体来说，我们将研究饮食限制的依从性、身体活动水平、月经、激素水平和微量营养水平是否与骨密度有关。