ANABOLIC EFFECT OF GROWTH HORMONE IN INBORN ERRORS OF METABOLISM

生长激素对先天性代谢缺陷的合成代谢作用

• 批准号: 5221227
• 负责人: DEBORAH L MARSDEN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5221227
• 关键词: alanine; bone density; cephalometry; child (0-11); child physical development; clinical research; diet therapy; dietary supplements; glycogen storage disease; hormone therapy; human subject; human therapy evaluation; inborn metabolism disorder; metabolism disorder chemotherapy; muscle disorders; nutrition related tag; osteoporosis; somatotropin

To establish whether growth hormone or alanine supplementation will improve linear growth or rates of increase in weight or head circumference in patients with inborn errors of metabolism requiring diets severely restricted in protein or in patients with glycogen storage disease, whether treatment can decrease catabolic production of toxic metabolites, whether myopathy is reduced and to assess effects on bone density to ameliorate osteoporosis.

为了确定补充生长激素或丙氨酸是否会 改善线性增长或体重或头部的增加率 先天性代谢性疾病患者的腰围 严格限制蛋白质饮食或糖原储存患者的饮食 疾病，治疗能否减少分解代谢产生的毒性 代谢产物，肌病是否减轻，并评估对骨骼的影响 密度改善骨质疏松症。