GLUCOSE METABOLISM IN VIOLENT ALCOHOLICS

暴力酗酒者的葡萄糖代谢

• 批准号: 2293674
• 负责人: MATTI VIRKKUNEN
• 金额: $ 13.89万
• 依托单位: UNIVERSITY OF HELSINKI
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1997-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2293674
• 关键词: GLUCOSE; METABOLISM; VIOLENT; ALCOHOLICS

The proposed contract is designed to determine the meaning of low CSF 5- HIAA concentrations and impaired insulin metabolism found in a large portion of impulsive alcoholics. The specific question addressed by the proposed study is to elucidate why a large proportion of impulsive violent alcoholics, who have a low CSF 5- HIAA concentration, become mildly hypoglycemic after an oral glucose load. The answer to this question should be clear after the results of the tests and procedures undertaken in this study are analyzed. To achieve this objective, we propose A. To classify impulsive, alcoholic violent offenders and healthy controls using structured interviews to permit assignment of accurate diagnosis of psychiatric disorders, alcoholism and/or drug abuse. Alcoholics who meet the criteria and controls free from psychiatric disorders, alcoholism and/or drug abuse will be studied further. B. To study whole genomic RFLPs and targeted genetic markers in impulsive, alcohol abusing, violent offenders and healthy volunteers for genetic associations. C. To investigate glucose metabolism in detail in violent alcoholics with a low and normal CSF 5-HIAA and in healthy volunteers.

拟议的合同旨在确定低 CSF 5- 的含义 在大量人群中发现 HIAA 浓度和胰岛素代谢受损 一部分冲动的酗酒者。 拟议研究解决的具体问题是阐明为什么 很大一部分冲动暴力酗酒者的 CSF 5- 较低 HIAA 浓度，口服葡萄糖负荷后出现轻度低血糖。 这个问题的答案应该在测试结果之后就清楚了 并对本研究中采取的程序进行了分析。 为了实现这一目标，我们建议 A. 对冲动、酗酒的暴力犯罪者进行分类并进行健康控制 使用结构化访谈来准确诊断 精神疾病、酗酒和/或滥用药物。 遇见的酗酒者 没有精神疾病、酗酒的标准和控制 和/或药物滥用将得到进一步研究。 B. 研究冲动中的全基因组 RFLP 和靶向遗传标记 酗酒、暴力犯罪者和遗传健康志愿者 协会。 C. 详细研究暴力酗酒者的葡萄糖代谢 健康志愿者的 CSF 5-HIAA 较低且正常。