GLUCOSE METABOLISM IN VIOLENT ALCOHOLICS

拟议的合同旨在确定低脑脊液5- HIAA浓度和胰岛素代谢受损在一组 冲动酗酒者的一部分。 拟议的研究解决的具体问题是澄清为什么 很大一部分冲动的暴力性酗酒者，他们的脑脊液含量很低 HIAA浓度，在口服葡萄糖负荷后变得轻度低血糖。 在测试结果出来后，这个问题的答案应该会很清楚 并对本研究中采用的程序进行了分析。 为了达到这一目标，我们建议 A.对冲动、酗酒的暴力犯罪者和健康对照进行分类 使用结构化面谈，允许分配准确的诊断 精神障碍、酗酒和/或药物滥用。相遇的酒鬼 无精神障碍、无酒精中毒的标准和对照 和/或药物滥用将得到进一步研究。 B.研究全基因组RFLP和靶向遗传标记 酗酒、暴力犯罪者和健康的基因志愿者 联想。 C.详细研究重度酗酒者的葡萄糖代谢 正常和低水平的脑脊液5-HIAA和健康志愿者。

The proposed contract is designed to determine the meaning of low CSF 5- HIAA concentrations and impaired insulin metabolism found in a large portion of impulsive alcoholics. The specific question addressed by the proposed study is to elucidate why a large proportion of impulsive violent alcoholics, who have a low CSF 5- HIAA concentration, become mildly hypoglycemic after an oral glucose load. The answer to this question should be clear after the results of the tests and procedures undertaken in this study are analyzed. To achieve this objective, we propose A. To classify impulsive, alcoholic violent offenders and healthy controls using structured interviews to permit assignment of accurate diagnosis of psychiatric disorders, alcoholism and/or drug abuse. Alcoholics who meet the criteria and controls free from psychiatric disorders, alcoholism and/or drug abuse will be studied further. B. To study whole genomic RFLPs and targeted genetic markers in impulsive, alcohol abusing, violent offenders and healthy volunteers for genetic associations. C. To investigate glucose metabolism in detail in violent alcoholics with a low and normal CSF 5-HIAA and in healthy volunteers.