GLUCOSE METABOLISM IN VIOLENT ALCOHOLICS

暴力酗酒者的葡萄糖代谢

• 批准号: 2741370
• 负责人: MATTI VIRKKUNEN
• 金额: --
• 依托单位: UNIVERSITY OF HELSINKI
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2741370
• 关键词: Scandinavian country; alcoholism /alcohol abuse; behavioral /social science research tag; cerebrospinal fluid; genetic markers; glucose metabolism; human subject; hydroxyindoleacetate; impulsive behavior; neurotransmitter metabolism; restriction fragment length polymorphism; serotonin; violence

The proposed contract is designed to determine the meaning of low CSF 5- HIAA concentrations and impaired insulin metabolism found in a large portion of impulsive alcoholics. The specific question addressed by the proposed study is to elucidate why a large proportion of impulsive violent alcoholics, who have a low CSF 5- HIAA concentration, become mildly hypoglycemic after an oral glucose load. The answer to this question should be clear after the results of the tests and procedures undertaken in this study are analyzed. To achieve this objective, we propose A. To classify impulsive, alcoholic violent offenders and healthy controls using structured interviews to permit assignment of accurate diagnosis of psychiatric disorders, alcoholism and/or drug abuse. Alcoholics who meet the criteria and controls free from psychiatric disorders, alcoholism and/or drug abuse will be studied further. B. To study whole genomic RFLPs and targeted genetic markers in impulsive, alcohol abusing, violent offenders and healthy volunteers for genetic associations. C. To investigate glucose metabolism in detail in violent alcoholics with a low and normal CSF 5-HIAA and in healthy volunteers.

拟议的合同旨在确定低CSF 5的含义- HIAA浓度和受损的胰岛素代谢发现，在一个大的 一部分冲动的酒鬼 拟议的研究所要解决的具体问题是， 很大一部分冲动的暴力酗酒者，他们的CSF 5很低， HIAA浓度，在口服葡萄糖负荷后变为轻度低血糖。 这个问题的答案应该在测试结果出来后就清楚了 和程序进行了分析。 为达致这个目标，我们建议 A.将冲动的酗酒暴力犯罪者和健康对照者进行分类 使用结构化访谈，以允许分配准确的诊断， 精神障碍、酗酒和/或药物滥用。 酗酒者见面 标准和对照无精神障碍、酗酒 和/或药物滥用将进一步研究。 B。目的研究冲动型抑郁症患者全基因组RFLP和靶向遗传标记， 酒精滥用，暴力罪犯和健康志愿者的遗传 协会. C.为了详细研究重度酗酒者的葡萄糖代谢， 低和正常的CSF 5-HIAA和健康志愿者。

项目成果

Low non-oxidative glucose metabolism and violent offending: an 8-year prospective follow-up study.

低非氧化葡萄糖代谢和暴力犯罪：一项为期 8 年的前瞻性随访研究。

• DOI: 10.1016/j.psychres.2008.03.026
• 发表时间: 2009
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Virkkunen,Matti;Rissanen,Aila;Franssila-Kallunki,Anja;Tiihonen,Jari
• 通讯作者: Tiihonen,Jari

Energy substrate metabolism among habitually violent alcoholic offenders having antisocial personality disorder.

患有反社会人格障碍的习惯性暴力酗酒者的能量底物代谢。

• DOI: 10.1016/j.psychres.2006.01.013
• 发表时间: 2007
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Virkkunen,Matti;Rissanen,Aila;Naukkarinen,Hannu;Franssila-Kallunki,Anja;Linnoila,Markku;Tiihonen,Jari
• 通讯作者: Tiihonen,Jari